Clinical Psychopharmacology and Neuroscience Papers in Press available online.

 
INVESTIGATING THE RELATIONSHIP OF SERUM CD163, YKL40 AND VILIP-1 LEVELS WITH AUTISM SEVERITY AND LANGUAGE-COGNITIVE DEVELOPMENT IN PRESCHOOL CHILDREN WITH AUTISM.
Samet Can Demirci 1,2,*, Süreyya Barun 3, Ahmet Özaslan 1,4, Özlem Gülbahar 5, Tuba Saadet Deveci Bulut 5, Aysu Duyan Çamurdan 6, Elvan İşeri 1
1Child and Adolescent Psychiatry Department, Gazi University Medical Faculty, Ankara, Turkey. , 2Child and Adolescent Psychiatry Department, Ardahan State Hospital, Ardahan, Turkey, 3Medical Pharmacology Department, Gazi University Medical Faculty, Ankara, Turkey., 4Autism and Developmental Disorders Application and Research Center, Gazi University Ankara, Turkey., 5Medical Biochemistry Department, Gazi University Medical Faculty, Ankara, Turkey, 6Child Health and Diseases Department, Gazi University Medical Faculty, Ankara, Turkey
Abstract
Objectives: This study aimed to compare serum levels of CD163, YKL-40, and VILIP-1 between children with autism spectrum disorder (ASD) and healthy controls, while also investigating their association with the severity of ASD and language development.
Methods: The study included 40 ASD-diagnosed patients (aged 18-72 months) and 40 age-matched healthy controls. Childhood Autism Rating Scale (CARS), Preschool Language Scale-4 (PLS-4), and Ankara Development Screening İnventory (ADSI) were administered to children in the ASD group. Serum CD163, YKL-40 and VILIP-1 levels were measured with an enzyme-linked immunosorbent assay kit.
Results: In the ASD group compared to the control group, serum VILIP-1 levels were significantly higher (p=0.046). No significant differences were observed in mean serum CD163 and YKL-40 levels between patients and controls (p=0.613, p=0.769). Interestingly, a positive correlation was observed between CD163 and YKL-40 levels and ASD severity (p<0.001 for both). Additionally, CD163 and YKL-40 levels showed significant predictive value for ASD severity. While no significant associations were found between CD163 and YKL-40 levels and language development, a negative correlation was observed between VILIP-1 levels and language development (p<0.001).
Conclusion: Our findings highlight that the levels of CD163 and YKL-40 significantly predicted ASD severity, indicating a potential role of neuroinflammation in the development of ASD.
Accepted Manuscript [Submitted on 2023-11-19, Accepted on 2024-03-27]