Clinical Psychopharmacology and Neuroscience Papers in Press available online.

The dropout rates and associated factors in patients with mood disorders in long-term naturalistic treatment
Wooyoung Jung 1, Eunsoo Moon 2,3,*, Hyun Ju Lim 2, Je Min Park 2,3, ByungDae Lee 2,3, Young Min Lee 2,3, Heejeong Jeong 2, Hwagyu Suh 2, Kyungwon Kim 2
1Jung Wooyoung Psychiatry Clinic, Busan, Republic of Korea, 2Department of Psychiatry and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea , 3Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Republic of Korea
Objective: Although maintenance treatment for mood disorders is important, the treatment discontinuation rate is reported to be high. This study aimed to investigate the dropout rates and associated factors in mood disorders.
Methods: The patients in a mood disorder clinic (n=535) were examined. Demographic and clinical factors, scores of psychometric scales, time to dropout from initial treatment in patients with bipolar disorder (BP) (n=288) and depressive disorder (DD) (n=143) were evaluated based on database of the mood disorder clinic.
Results: Among the studied patients with BP and DD, 50% showed dropout in 4.05 and 2.17 years, respectively. The mean survival times were 8.90 years in bipolar disorder I (BP-I), 5.19 years in bipolar II disorder, 3.22 years in bipolar disorder not otherwise specified, 4.24 years in major depressive disorder, and 4.03 years in other depressive disorders. In the multivariate Cox proportional hazards regression model in the BP group, diagnosis BP-I was found to be significantly related to the decrease in dropout rate (HR= 0.22, p=0.001); however, increased past suicide attempt number was significantly related to the increase in dropout rate (HR=1.13, p=0.017). In the DD group, none of anxiety disorders as comorbidity, increased scores of openness, and extraversion personality were related to the increase in dropout rate.
Conclusion: Patients with BP, especially BP- I, showed a lower dropout rate as compared to patients with other mood disorders.
Accepted Manuscript [Submitted on 2023-04-03, Accepted on 2023-05-22]