Clinical Psychopharmacology and Neuroscience Papers in Press available online.

Transdiagnostic associations between anger hostility and chemokine interferon-gamma inducible protein 10 (CXCL 10)
Hedda Soloey-Nilsen 1,2,*, Kristin Nygaard-Odeh1,2, Magnhild Gangsoey Kristiansen1,2, Erling Inge Kvig1,2, Ole Lars Brekke1,2, Tom Eirik Mollnes1,4,5,6, Michael Berk7,8, Solveig Klaebo Reitan3,9, Terje Oiesvold1,2
1Nordland Hospital Trust, Department of mental health and addiction medicine, Bodoe, Norway, 2Institute of Clinical Medicine, UIT The Arctic University of Norway, Tromsoe, Norway, 3Department of Mental Health IPH, Faculty of Medicine and Health sciences, Norwegian university of science and technology, NTNU, Trondheim, Norway., 4Research Laboratory, Nordland Hospital Trust, Bodoe, Norway., 5Department of Immunology, Oslo University Hospital and University of Oslo, Norway., 6Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway., 7Deakin University, IMPACT – the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia., 8Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, The University of Melbourne, Melbourne, Australia., 9St Olavs Hospital, Nidelv community center of mental health, Trondheim, Norway.
Many psychiatric disorders are linked to low grade systemic inflammation as measured by systemic cytokine levels. Exploration of cytokines and immune activity and their role in psychiatric symptoms may inform pathobiology and treatment opportunities.
This was a cross sectional naturalistic study with 132 participants from a general open inpatient psychiatric ward at the Nordland Hospital Trust, Norway. Serum levels of 28 different cytokines were assessed. Psychiatric symptoms the last week were assessed by a self-rating scale (Symptom check list, SCL-90- R) and grouped in defined clusters. Multiple linear regression model was used for statistical analyses of associations between levels of cytokines and symptoms, adjusting for possible confounding factors.
We found a positive association (p 0.009) between the chemokine interferon-gamma inducible protein 10 (CXCL 10; IP-10) and the anger hostility cluster. No associations were found between the other symptom clusters and cytokines. IP-10 and the anger hostility cluster were positively associated (p 0.002) in the subgroup of patients using psychotropic medication, not in the subgroup not using psychotropic medication.
Our analyses revealed a significant positive association between the symptom cluster anger hostility in SCL-90-R and the chemokine IP-10 in the subgroup of patients using psychotropic medications.

Keywords: Immune system, cytokines, psychiatry, neuroscience, IP-10; interferon-gamma inducible protein, anger hostility.
Accepted Manuscript [Submitted on 2023-04-01, Accepted on 2023-05-24]