Clinical Psychopharmacology and Neuroscience Papers in Press available online.

The association between default-mode network functional connectivity and childhood trauma on the symptom load in male adults with methamphetamine use disorder
Shyh-Yuh Wei 1, Tsung-Han Tsai 1, Tsung-Yu Tsai 1, Po See Chen 1,2, Huai-Hsuan Tseng 1,2, Yen Kuang Yang 1,2,3, Tianye Zhai 4, Yihong Yang 4, Tzu-Yun Wang 1,2,*
1Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 2Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 3Department of Psychiatry, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan, 4Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
Objective: The relationship between adverse childhood experiences and methamphetamine use disorder (MUD) has been shown in previous studies; nevertheless, the underlying neural mechanisms remain elusive. Childhood trauma is associated with aberrant functional connectivity (FC) within the default-mode network (DMN). Furthermore, within the DMN, FC may contribute to impaired self-awareness in addiction, while cross-network FC is critical for relapse. We aimed to investigate whether childhood trauma was associated with DMN-related resting-state FC among healthy controls and patients with MUD and to examine whether DMN-related FC affected the effect of childhood trauma on the symptom load of MUD diagnosis.
Methods: Twenty-seven male patients with MUD and 27 male healthy controls were enrolled and completed the Childhood Trauma Questionnaire (CTQ). DMN-related resting-state FC was examined using functional magnetic resonance imaging.
Results: There were 47.1% healthy controls and 66.7% MUD patients in this study with adverse childhood experiences. Negative correlations between adverse childhood experiences and within-DMN FC were observed in both healthy controls and MUD patients, while within-DMN FC was significantly altered in MUD patients. The detrimental effects of adverse childhood experiences on MUD patients may be attenuated through DMN-executive control networks (ECN) FC.
Conclusion: Adverse childhood experiences were negatively associated with within-DMN FC in MUD patients and healthy controls. However, DMN-ECN FC may attenuate the effects of childhood trauma on symptoms load of MUD.
Accepted Manuscript [Submitted on 2023-03-25, Accepted on 2023-08-14]