Clinical Psychopharmacology and Neuroscience Papers in Press available online.

The Relationship Between Depression Severity and Prefrontal Hemodynamic Changes in Adolescents with Major Depression Disorder: A Functional Near-Infrared Spectroscopy Study
Jeong Eun Shin , Yun Sung Lee , Seo Young Park , Mi Young Jeong , Yeon Jung Lee
1Department of Medical Sciences, Graduate School of Soonchunhyang University, Asan, Chungnam, Republic of Korea , 2Sejong Special Self-Governing City Mental Health Welfare Center, Sejong, Republic of Korea, 3Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 4Department of Psychiatry, Soonchunhyang University College of Medicine, Seoul Hospital, Seoul, Republic of Korea
Objective: Numerous studies have identified hemodynamic changes in adults with major depressive disorder (MDD) by using functional near-infrared spectroscopy (fNIRS). However, studies on adolescents with MDD are limited. As adolescence is a stage of rapid brain development, differences may occur depending on age. This study used fNIRS as an objective tool to investigate hemodynamic changes in the frontal lobe according to depression severity and age in adolescents with MDD.
Methods: Thirty adolescents (12 aged 12–15 years and 18 aged 16–18 years) were retrospectively investigated. The Children’s Depression Inventory was used as a psychiatric evaluation scale, fNIRS was used as an objective brain function evaluation tool, and the Verbal Fluency Test was performed.
Results: During the Verbal Fluency Test, in the younger MDD group, oxygenated-hemoglobin concentration increased in the right dorsolateral prefrontal cortex region as the severity of depression increased. In the older MDD group, the oxygenated-hemoglobin concentration decreased in the right dorsolateral prefrontal cortex region as the severity of depression increased.
Conclusion: These results suggest that fNIRS may be an objective tool for identifying age differences among adolescents with MDD. To generalize the results and verify fNIRS as a potential biomarker tool, follow-up studies with a larger sample group should be conducted.
Accepted Manuscript [Submitted on 2023-03-07, Accepted on 2023-06-17]