Clinical Psychopharmacology and Neuroscience Papers in Press available online.

The importance of low-frequency alpha (8-10 Hz) waves and default mode network in behavioral inhibition
Yong-Wook Kim1,2, Sungkean Kim3, Min Jin Jin1,4, Chang-Hwan Im 2, Seung-Hwan Lee 1,5,*
1Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, Republic of Korea, 2Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea, 3Department of Human-Computer Interaction, Hanyang University, Ansan, Republic of Korea, 4Institute of General Education, Kongju National University, Gongju, Republic of Korea, 5Department of Psychiatry, Inje University, Ilsan-Paik Hospital, Goyang, Republic of Korea
Alpha wave of electroencephalography (EEG) is known to be related to behavioral inhibition. Both the alpha wave and default mode network (DMN) are predominantly activated during resting-state. The research investigating behavioral inhibition in resting-state might be necessary to study the mechanisms of the trait inhibition.
We explored the relationship among behavioral inhibition, resting-state alpha power, and DMN. Resting-state EEG, behavioral inhibition/behavioral activation scale (BIS/BAS), Barratt impulsivity scale, and nogo accuracy were assessed in 104 healthy individuals. Three groups (i.e. participants with low/middle/high band power) were formed based on the relative power of each total-alpha, low-alpha (LA), and high-alpha band. Source-reconstructed EEG and functional network measures of 25 DMN regions were calculated.
Significant differences and correlations were found based on LA band power alone. The high LA group had significantly greater BIS, clustering coefficient, efficiency, and strength, and significantly lower path length than low/middle LA group. BIS score showed a significant correlation with functional network measures of DMN.
Our study revealed that LA power is related to behavioral inhibition and functional network measures of DMN of LA band appear to represent significant inhibitory function, than high-/total-alpha bands.
Accepted Manuscript [Submitted on 2022-10-17, Accepted on 2023-02-17]