Clinical Psychopharmacology and Neuroscience Papers in Press available online.

Efficacy of asenapine in drug-resistant psychotic patients with dopamine supersensitivity psychosis: Two cases
Nobuhisa Kanahara 1,*, Hiroshi Kimura2,3,4, Toshihiko Kinoshita5, Masaomi Iyo4, Yoshiteru Takekita5
1Center for Forensic Mental Health, Chiba University, 2Gakuji-kai Kimura Hospital, 3International University of Health and Welfare, 4Chiba University Graduate School of Medicine, 5Kansai Medical University
Dopamine supersensitivity psychosis (DSP) is an unstable clinical condition observed in individuals with schizophrenia who have been treated with an antipsychotic medication at a high dosage and/or for a long period. An up-regulation of dopamine D2 receptors (DRD2) is thought to be involved in the essential pathology of DSP. An antipsychotic agent with both tight binding to DRD2 and a long half-life is generally effective for treating DSP, but a patient who meets the criteria of treatment-resistant schizophrenia sometimes needs treatment with clozapine. We report the case details of two patients whose DSP was not controlled with several antipsychotics but was successfully controlled with asenapine. Asenapine binds to a broad range of dopamine receptors and serotonin receptors, and it is thus distinct from other atypical antipsychotics. The unique profile of asenapine may contribute to the control of severe DSP symptoms in individuals with schizophrenia.
Accepted Manuscript [Submitted on 2022-03-19, Accepted on 2022-05-20]