Clinical Psychopharmacology and Neuroscience Papers in Press available online.

The cumulative effect of antipsychotic usage on mortality in schizophrenia: A nationwide population-based cohort study in Korea
Gyurin Kim 1, Soo Jung Rim 1, Minkyung Jo 1, Min Geu Lee 1, Se Jin Park 1, Subin Park 2,*
1Department of Research Planning, National Center for Mental Health, 2Mental Health Research Institute, National Center for Mental Health
Objective: To investigate the cumulative effect of antipsychotics at different dosages on mortality in patients with schizophrenia.
Methods: We analyzed data from the Korean National Health Insurance System–National Sample Cohort covering the 2002–2013 period. We used Cox regression analysis to calculate hazard ratios for mortality risks according to cumulative antipsychotic exposure levels (low, moderate, and high).
Results: Our analyses revealed no significant association between antipsychotic exposure and mortality (either all-cause or cause-specific) in patients with schizophrenia.
Conclusion: Our results imply that the excess mortality of patients with schizophrenia is attributable to factors other than antipsychotic usage.
Accepted Manuscript [Submitted on 2021-12-09, Accepted on 2022-04-10]