Clinical Psychopharmacology and Neuroscience Papers in Press available online.

 
Targeting three brain regions (bilateral SMA, left and right DLPFC) sequentially in one session using combined repetitive transcranial magnetic stimulation and intermittent theta-burst stimulation in treatment-refractory obsessive-compulsive disorder: a case report
Po-Han Chou 1,2, Alexander T Sack 3, Kuan-Pin Su 4,5,6,*
1Department of Psychiatry, China Medical University Hsinchu Hospital, China Medical University, Hsinchu, Taiwan., 2Department of Psychiatry, China Medical University Hospital, China Medical University, Taichung, Taiwan., 3Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands., 4College of Medicine, China Medical University, Taichung, Taiwan., 5Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan. , 6An-Nan Hospital, China Medical University, Tainan, Taiwan.
Abstract
Repetitive transcranial magnetic stimulation (rTMS) has been widely used as a therapy for refractory obsessive-compulsive disorder (OCD). However, it remains unclear which exact target and stimulation sequence of rTMS is most effective for OCD. Here, we report the case of an 18-year-old woman with treatment-refractory OCD whose symptoms markedly improved after combined rTMS and intermittent theta-burst stimulation over the bilateral dorsolateral prefrontal cortex and supplementary motor area. Our report indicates that combining treatment sequences that stimulate different brain regions sequentially is feasible and may clinically benefit patients suffering from OCD.
Accepted Manuscript [Submitted on 2021-11-23, Accepted on 2021-11-29]