Clinical Psychopharmacology and Neuroscience Papers in Press available online.

 
Plasminogen Activator Inhibitor-1: Potential Inflammatory Marker in Late-life Depression
Seung-Hoon Lee 1, Cheolmin Shin 2, Young-Hoon Ko 2, Moon-Soo Lee 2, Moon Ho Park 3, Chi-Un Pae 4, Ho-Kyoung Yoon 2, Changsu Han 2,*
1Department of Psychiatry, Veterans Health Service Medical Center, Seoul, Republic of Korea, 2Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea, 3Department of Neurology, College of Medicine, Korea University, Seoul, Republic of Korea, 4Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Abstract
Objective: Although several previous studies have examined the association between late-life depression and blood adipokine levels, a marker of chronic inflammation, no studies have comprehensively considered the effects of metabolic syndrome, which is known to affect blood adipokine levels. This study examined blood adipokine levels in geriatric depression after adjusting for the effects of metabolic syndrome.
Method: Participants were selected from the Ansan Geriatric Study (depression group [n = 76] and control group [n = 76]). Blood concentrations of four adipokines (adiponectin, resistin, neutrophil-gelatinase-associated lipocalin [NGAL], and plasminogen activator inhibitor-1 [PAI-1]) were measured using immunoassays. The effects of blood adipokine concentration on the diagnosis of depression were analyzed using multivariate logistic regression to adjust for the effects of metabolic syndrome and potential confounding factors.
Results: When the effects of metabolic syndrome and potential confounding factors were adjusted, only PAI-1 could explain the diagnosis of depression among all the adipokines. The depression group showed a lower blood PAI-1 level than the control group. Adiponectin, resistin, and NGAL could not explain the diagnosis of depression when the effects of metabolic syndrome and potential confounding factors were adjusted.
Conclusion: This study suggests the possibility that the blood PAI-1 levels in clinically pathological late-life depression may show contrasting results to those with subclinical depressive symptoms. Additionally, considering that most previous studies have been conducted with pre-geriatric populations, the study suggests the possibility that geriatric depression may show inflammatory changes with patterns that are different from those of depression in the pre-geriatric population.
Accepted Manuscript [Submitted on 2021-09-08, Accepted on 2021-10-27]