Clinical Psychopharmacology and Neuroscience Papers in Press available online.

 
Harm Avoidance is Correlated with the Reward System in Adult Patients with Attention Deficit Hyperactivity Disorder—A fMRI Study
Tsung-Hua Lu 1, Shih-Hsien Lin 1,2, Mei Hung Chi 1, Ching-Lin Chu 1, Dong-Yu Yang 1, Wei Hung Chang 1,3, Po See Chen 1,2, Yen-Kuang Yang 1,2,4,*
1Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 2Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 3Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan, 4Department of Psychiatry, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan
Abstract
Objective: Hypoactivity in the reward system among patients with attention deficit hyperactivity disorder (ADHD) is a well-known phenomenon. Whether the activity in the reward pathway is related to harm avoidance, such as in sensitivity to punishment, is unclear. Evidence regarding the potential difference between ADHD patients and controls in terms of this association is scarce.
Methods: Event-related functional magnetic resonance imaging was conducted on subjects performing the Iowa gambling test. Fourteen adults with ADHD and 14 controls were enrolled in the study.
Results: Harm avoidance was found to be positively correlated with the activities of the bilateral orbitofrontal cortex and right insula in individuals with ADHD. A group difference was also confirmed.
Conclusions: Understanding the roles of harm avoidance and brain activation during risk tasks is important.
Accepted Manuscript [Submitted on 2021-07-22, Accepted on 2021-11-25]