Clinical Psychopharmacology and Neuroscience Papers in Press available online.

Dynamic Thiol / Disulfide Homeostasis and Oxidative DNA Damage in Adult Attention Deficit Hyperactivity Disorder (ADHD)
Faruk Kurhan 1,1,1,*, hamit hakan alp 2,2,2
1Yuzuncu Yıl University, Psychiatry, Tusba, Van, Turkey, 2Yuzuncu Yıl University, Biochemistry department, Tusba, Van, Turkey
Background: Insufficient number of oxidative stress studies have been conducted in patients with adult attention deficit hyperactivity disorder (ADHD). The objective of the current study is to examine the thiol/disulfide homeostasis besides oxidative DNA damage levels in adult ADHD patients and to compare them with the results of healthy control subjects.
Methods: The study was inclusive of forty-nine patients who were diagnosed with adult ADHD, besides thirty-three healthy volunteers to be used as the control group. The diagnosis of the patients was conducted according to the DSM-5 diagnostic criteria. The oxidative DNA damage level, an extraction of genomic DNA from leukocytes was carried out, and furthermore the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG), apart from deoxyguanosine, were measured accordingly.
Results: Total thiol and the native thiol levels were observed to be lower in adult ADHD patients as compared to the subjects in the healthy control group (p = 0.001). It was observed that the disulfide levels were higher in adult ADHD patients as compared to the healthy control subjects (p = 0.001). The levels of 8-OHdG, which are considered as a marker for assessing DNA damage, were found to be lower in the control group as compared to the adult ADHD patients (p = 0.001).
Conclusion: It was observed that the thiol / disulfide homeostasis had shifted towards disulfide, and 8-OHdG levels were increased in adult ADHD patients. This result indicates that thiol/disulfide homeostasis could be important in the pathophysiology of oxidative stress in adult ADHD patients.
Accepted Manuscript [Submitted on 2021-01-04, Accepted on 2021-02-05]