Clinical Psychopharmacology and Neuroscience Papers in Press available online.

 
Could irisin levels be affected by physical activity in patients with schizophrenia?
Gamze Erzin , Olga Güriz , Ali Yalçındağ , Akfer Kahıloğulları , Sibel Örsel
1Health Sciences University Dışkapı Yıldırım Beyazıt Training and Research Hospital, Psychiatry Department, Ankara, Turkey, 2Health Sciences University Dışkapı Yıldırım Beyazıt Training and Research Hospital, Biochemistry Department, Ankara, Turkey
Abstract
The aim of this study was to explore the effect of physical activity and metabolic parameters on irisin levels in patients with schizophrenia and healthy controls. Ninety-six patients with schizophrenia and 63 healthy controls comprised the study population. The participants were separated into three groups: inactive, low activity, and sufficiently active according to IPAQ-SF.We measured irisin levels using Enzyme-linked immunosorbent assay (ELISA). We also calculated exercise levels by using the International Physical Activity Questionnaire short form (IPAQ-SF) for each individual. The independent samples t-test was used in the data analysis to compare irisin levels according to the activity levels of the patients with schizophrenia and controls. The levels of irisin were higher in the healthy controls (p<.001) compared to schizophrenia groups. When the activity levels of the schizophrenia and healthy control groups were compared, the irisin levels of the low activity and sufficiently active groups with schizophrenia were found to be lower than those of the low activity and sufficiently active groups in the healthy controls (respectively p=.014; p<.001). Irisin levels could be affected by physical activity and these results must be supported with new studies.
Accepted Manuscript [Submitted on 2020-08-13, Accepted on 2020-11-08]