miR-26b, miR-30e, and miR-206 Polymorphisms May Play a Role in BDNF-mediated Development of Alzheimer’s-type Dementia
Ayten Tuna1, Olcay Boyacioglu2, Ayse Dondu3, Seda Orenay-Boyacioglu4
1Molecular Biotechnology Program, Institute of Health Sciences, Aydın Adnan Menderes University, Efeler, Aydın, Türkiye
2Faculty of Engineering, Aydın Adnan Menderes University, Efeler, Aydın, Türkiye
3Department of Psychiatry, Faculty of Medicine, Aydın Adnan Menderes University, Efeler, Aydın, Türkiye
4Department of Medical Genetics, Faculty of Medicine, Aydın Adnan Menderes University, Efeler, Aydın, Türkiye
Correspondence to: Seda Orenay-Boyacioglu
Department of Medical Genetics, Faculty of Medicine, Aydın Adnan Menderes University, Efeler, Aydın 09010, Türkiye
E-mail: sorenay@adu.edu.tr
ORCID: https://orcid.org/0000-0003-1651-1940
Received: July 25, 2024; Revised: September 26, 2024; Accepted: October 8, 2024; Published online: November 4, 2024.
© The Korean College of Neuropsychopharmacology. All rights reserved.

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Abstract
Objective: The brain-derived neurotrophic factor (BDNF) playing a crucial role in neuron survival and function, particularly in neurodegenerative diseases like Alzheimer’s disease (AD). Our study seeks to explore polymorphisms in miRNAs that regulate the BDNF gene in individuals with AD, and to reveal the relationship between these polymorphisms and APOE genotypes.
Methods: Seventy AD patients who applied to the Psychiatry outpatient clinic were recruited for the study as well as 70 healthy individuals in the same age. The cases were examined for 5 miRNAs regulating BDNF and 2 APOE SNPs using the SNPType method on the Fluidigm platform.
Results: In comparisons of the genotype distributions for three polymorphisms (miR-206 rs16882131, miR-30e rs112439044, miR-26b rs188612260) (p < 0.01 all) and the allele frequencies for two polymorphisms (miR-30e rs112439044, miR-26b rs188612260 ) (p < 0.01) detected significant differences between groups. While the APOE ε4/ε4 genotype was detected in 4.50% of the AD group, no individual with this genotype was observed in the control group. When the correlation between miRNA polymorphisms and APOE genotypic distributions were investigated, the miR-30e rs10489167 polymorphism showed a statistically significant positive correlation with the ε3/ε3 genotype and a statistically significant negative correlation with the ε2/ε3 genotype (p < 0.08 and p < 0.001 respectively). On the other hand, the miR-30e rs112439044 polymorphism exhibited a statistically significant positive correlation with the ε2/ε2 and ε3/ε3 genotypes (p < 0.03 and p < 0.07, respectively).
Conclusion: These findings could potentially offer insights into the mechanisms underlying AD.
Keywords: Alzheimer’s disease; BDNF ; MicroRNA; Gene polymorphisms; APOE

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