Synergistic Effect of Coenzyme Q10 and L-Carnitine on Gliosis and Anhedonia, in a Rat Model of Multiple Sclerosis: An Immunohistochemical Study
Tayyaba Qureshi, Shabana Ali, Tayyaba Fahad
Department of Anatomy, Islamic International Medical College, Al-Mizan Campus, Rawalpindi, Pakistan
Correspondence to: Tayyaba Qureshi
Department of Anatomy, Islamic International Medical College, Al-Mizan Campus, 274 Main Peshawar Road, Rawalpindi 46000, Pakistan
E-mail: dr.tayyabaqureshi@gmail.com
ORCID: https://orcid.org/0000-0001-7200-835X
Received: December 11, 2023; Revised: May 4, 2024; Accepted: June 11, 2024; Published online: June 28, 2024.
© The Korean College of Neuropsychopharmacology. All rights reserved.

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objective: This study provides histological evidence of the combined effects of L-Carnitine, and Coenzyme Q10 on gliosis and anhedonia in a rat model of multiple sclerosis (MS).
Methods: Fifty male Sprague Dawley rats were randomly divided into 5 groups of 10 rats each. Group 1 was the control group. The rest of the groups were disease models and were given 0.2% cuprizone w/w to induce MS. After 4 weeks, Group 3 started receiving L-Carnitine, Group 4 was given Coenzyme Q10, and Group 5 received both, while cuprizone poisoning continued. After 12 weeks sucrose preference test and tail suspension test were performed for anhedonia. Rats were euthanized and brains were dissected, and assessed for astrocytes, oligodendrocytes, and microglial count.
Results: A significant increase in oligodendrocyte count, while a reduction in astrocyte and microglial count was seen in the synergistic group (p < 0.05). Synergism could not be proved in anhedonia.
Conclusion: The combination of Coenzyme Q10 and L-Carnitine has a synergistic effect in controlling gliosis in a rat model of MS, but synergism could not be demonstrated on anhedonia.
Keywords: Multiple sclerosis; Cuprizone; Carnitine; Coenzyme Q10; Gliosis


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