Synergistic effect of Coenzyme Q10 and L-Carnitine on Gliosis and Anhedonia, in a rat model of Multiple Sclerosis; An Immunohistochemical study.
Tayyaba Qureshi *, Shabana Ali , Tayyaba Fahad
Islamic International Medical College, Rawalpindi, Pakistan
Received: November 22, 2023; Revised: June 11, 2024; Accepted: June 11, 2024; Published online: June 11, 2024.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: This study provides histological evidence of the combined effects of L-Carnitine, and CoenzymeQ10 on gliosis and anhedonia in a rat model of multiple sclerosis.
Methodology: Fifty male Sprague Dawley rats were randomly divided into 5 groups of 10 rats each. Group 1 was the control group. The rest of the groups were disease models and were given 0.2% Cuprizone w/w to induce Multiple Sclerosis. After 4 weeks, Group 3 started receiving L-Carnitine, Group 4 was given CoenzymeQ10, and Group 5 received both, while Cuprizone poisoning continued. After 12 weeks sucrose preference test and tail suspension test were performed for anhedonia. Rats were euthanized and brains were dissected, and assessed for astrocytes, oligodendrocytes, and microglial count.
Results: A significant increase in oligodendrocyte count, while a reduction in astrocyte and microglial count was seen in the synergistic group (p<0.05). Synergism could not be proved in anhedonia.
Conclusion: The combination of CoenzymeQ10 & and L-Carnitine has a synergistic effect in controlling gliosis in a rat model of MS, but synergism could not be demonstrated on anhedonia.
Keywords: Multiple sclerosis, Cuprizone, Coenzyme Q10, L-Carnitine, Gliosis, Anhedonia


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