Successful Electroconvulsive Therapy for Tardive Dyskinesia and Tardive Dystonia Refractory to Valbenazine Treatment: A Case Report and Narrative Literature Review
Keisuke Irinaka 1, Yu Itoh 1, Kazuhisa Yoshizawa 1, Masaya Ogasawara 1, Naoko Ayabe 2, Kazuo Mishima , masahiro takeshima 1*
1Department of Neuropsychiatry, Akita University Graduate School of Medicine, 2Department of Regional Studies and Humanities, Faculty of Education and Human Studies, Akita University
Received: February 26, 2024; Revised: May 24, 2024; Accepted: June 11, 2024; Published online: June 11, 2024.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Tardive dyskinesia and dystonia are intractable extrapyramidal symptoms caused by the blockade of dopamine receptors by antipsychotic drugs. In addition to the reduction or discontinuation of the causative drug, valbenazine for tardive dyskinesia and botulinum toxin for tardive dystonia have been reported to be effective; however, their efficacy has not been fully demonstrated. Here, we report the case of a female patient with bipolar disorder, valbenazine-resistant tardive dystonia, and tardive dyskinesia, who achieved improvement in extrapyramidal symptoms with electroconvulsive therapy. Additionally, we conducted a narrative literature review on the safety and efficacy of electroconvulsive therapy for tardive dyskinesia and dystonia.
Keywords: electroconvulsive therapy, valbenazine, tardive dyskinesia, tardive dystonia