Psychometric Properties of the Korean Version of THINC-integrated Tool (THINC-it-K): A Tool for Screening Assessment of Cognitive Function in Patients with Major Depressive Disorder
Young Sup Woo1, Kyoung-Uk Lee1, Changtae Hahn1, Roger S. McIntyre2,3,4, Kayla M. Teopiz4, Won-Myong Bahk1
1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea
2Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
3Department of Psychiatry, University of Toronto, Toronto, ON, Canada
4Brain and Cognition Discovery Foundation, Toronto, ON, Canada
Correspondence to: Won-Myong Bahk
Department of Psychiatry, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 10 63-ro, Yeongdeungpo-gu, Seoul 07345, Korea
Received: October 2, 2023; Accepted: October 25, 2023; Published online: November 30, 2023.
© The Korean College of Neuropsychopharmacology. All rights reserved.

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Objective: The present study was performed to investigate the validity and reliability of the Korean version of the THINC-it tool (THINC-it-K) in adult patients with major depressive disorder (MDD).
Methods: Subjects aged 19−65 years with recurrent MDD experiencing moderate to severe major depressive episode (n = 44) were evaluated and compared to age and sex matched healthy controls (n = 44). Subjects completed the THINC-it-K which includes variants of the Identification Task (IDN) using Choice Reaction Time, One-Back Test, Digit Symbol Substitution Test, Trail Making Test-Part B, and the Perceived Deficits Questionnaire for Depression-5-item (PDQ-5-D).
Results: A total of 75.0% of patients with MDD exhibited cognitive performance 1 standard deviation or below. The differences in Spotter (p = 0.001), Codebreaker (p = 0.001), PDQ-5-D (p < 0.001) and objective THINC-it-K composite score (p = 0.002) were significant between the two groups. Concurrent validity of the THINC-it-K based on a calculated composite score was good (r = 0.856, p < 0.001), and ranges for each component tests were from 0.076 (IDN) to 0.928 (PDQ-5-D).
Conclusion: The THINC-it-K exhibits good reliability and validity in adults with MDD. It could be a useful tool for the measurement of cognitive deficits in persons with MDD and should be implemented in clinical practice.
Keywords: Major depressive disorder; Cognitive impairment; THINC-it tool; Reliability; Validity.

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