Neuromolecular Etiology of Bipolar Disorder: Possible Therapeutic Targets of Mood Stabilizers
Jung Goo Lee 1, 2, 3, Young Sup Woo 4, Sung Woo Park 2, 3, 5, Dae-Hyun Seog 6, 7, Mi Kyoung Seo 2, Won-Myong Bahk 4*
1Department of Psychiatry, College of Medicine, Haeundae Paik Hospital, Inje University, Busan, Korea, 2Paik Institute for Clinical Research, Inje University, Busan, Korea, 3Department of Health Science and Technology, Graduate School, Inje University, Busan, Korea, 4Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea, 5Department of Convergence Biomedical Science, College of Medicine, Inje University, Busan, Korea, 6Department of Biochemistry, Inje University College of Medicine, Busan, Korea, 7Dementia and Neurodegenertive Disease Research Center, Inje University College of Medicine, Busan, Korea.
Received: August 25, 2021; Accepted: August 30, 2021; Published online: August 30, 2021.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Bipolar disorder is a mental illness that causes extreme mood swings and has a chronic course. However, the mechanism by which mood episodes with completely opposite characteristics appear repeatedly, or a mixture of symptoms appears, in patients with bipolar disorder remains unknown. Therefore, mood stabilizers are indicated only for single mood episodes, such as manic episodes and depressive episodes, and no true mood-stabilizing drugs effective for treating both manic and depressive episodes currently exist. Therefore, in this review, therapeutic targets that facilitate the development of mood stabilizers were examined by reviewing the current understanding of the neuromolecular etiology of bipolar disorder.
Keywords: Bipolar disorder, Mood stabilizer, Neurobiology


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