Alterations of power spectral density in salience network during thought-action fusion induction paradigm in obsessive-compulsive disorder
Sang Won Lee 1, 2, Eunji Kim 3, Tae Yang Jang 2, 4, Heajung Choi 3, Seungho Kim 3, Huijin Song 5, Moon Jung Hwang 6, Yongmin Chang 7, 8, Seung Jae Lee 2, 4*
1Department of Psychiatry, Kyungpook National University Chilgok Hospital, Daegu, Korea, 2Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Korea, 3Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, 4Department of Psychiatry, Kyungpook National University Hospital, Daegu, Korea, 5Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, 6GE Health Korea, Seoul, Korea, 7Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu, Korea, 8Department of Radiology, Kyungpook National University Hospital, Daegu, Korea
Received: December 4, 2020; Revised: March 30, 2021; Accepted: April 29, 2021; Published online: April 29, 2021.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: Recent studies highlighted the triple-network model which illustrated the interactions among three large-scale networks including salience network (SN). The functional magnetic resonance imaging used in this study was designed to investigate the characteristics of three large-scale networks associated with the thought–action fusion (TAF) in patients with obsessive–compulsive disorder (OCD) using power spectral density (PSD) analysis.
Methods: This study included 32 OCD patients and 38 age-matched healthy controls. The TAF task was modified from the experiment of Rassin. PSD from time courses in large-scale networks of each subject was measured to compare between the groups for both TAF and resting state.
Results: In SN, OCD reported lower power in the low-frequency domain of SN compared to healthy control (HC) using the two-sample t-test during the TAF task (t = −2.395, p = 0.019) but not in the resting state. The PSD in the low-frequency domain of the SN had a significant negative correlation with state score in the guilty inventory (r = −0.296, p = 0.013) in OCD patients with or without HC.
Conclusions: This study suggests that OCD patients showed reduced SN power which can be prominent in a certain situation, such as TAF. In addition, the PSD alterations in SN cause difficulty in processing ambiguous emotional cues in social situations, and the difficulty can be connected with a negative feeling (e.g., guilt).
Keywords: obsessive-compulsive disorder, power spectral density, salience network, triple-network model


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