Acute hepatitis due to agomelatine use in older women with depression? a case series
Cheng-Chen Chang 1, 2, Yen-Jen Chen 1, Yu-An Chen 1, Yi-Cheng Liao 1*
1Department of Psychiatry, Changhua Christian Hospital, Changhua, Taiwan, 2School of Medicine, Chung Shan Medical University, Taichung, Taiwan
Received: December 7, 2020; Revised: January 31, 2021; Accepted: February 1, 2021; Published online: February 1, 2021.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is a risk factor in developing hepatotoxicity due to agomelatine is not clear. We present 3 elderly female cases with acute hepatitis occurring due to highly probable idiosyncratic drug-induced liver injury caused by agomelatine. From these cases, regular surveillance on liver function in the elderly women taking antidepressants would be of benefits.
Keywords: agomelatine, acute hepatitis, major depression