Fig. 1. (A) Excitotoxic insults (glutamate, 10–5,000 μM; N-methyl-D-aspartate, 100–1,000 μM; kainic acid, 100–1,000 μM; exposure time, 24 hr) do not significantly modify cell viability in SH-SY5Y cells. (B) Exposure of SH-SY5Y cells to H2O2 (200 μM/24 hr) induces a ~50% cell death (†p<0.001 vs. vehicle-treated cells) and riluzole co-exposure (0.5–10 μM/24 hr) significantly prevents H2O2-induced cell death (*p < 0.01 vs. H2O2-treated cells); riluzole exposure (10 μM) alone does not modify cell viability in the same cells.
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