Clinical Psychopharmacology and Neuroscience indexed in CAS, DOI/Crossref, EMBASE, Korea Citation Index (KCI), KoreaMed, Korea Medical Citation Index (KoMCI), PubMed, PubMed Central (PMC), SCOPUS, SCI-expanded (SCIE), and Google Scholar:eISSN 2093-4327   pISSN 1738-1088

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Fig. 2. Chronic stress models were established successfully and fluoxetine intervention improved depression-like behavior stress–induced in mice and rats. (A) Sucrose preference in SPT of mice at the end of CUMS. (B) Central area distance in OFT of mice at the end of CUMS. (C) Immobility time in TST of mice at the end of CUMS. (D) Immobility time in FST of mice at the end of CUMS (n = 10 in NC group, n = 20 in CUMS group). (E) Sucrose preference in SPT of mice at the end of treatment. (F) Central area distance in OFT of mice at the end of treatment. (G) Immobility time in TST of mice at the end of treatment. (H) Immobility time in FST of mice at the end of treatment (n = 10/group). (I) Sucrose preference in SPT of rats at the end of CUMS. (J) Central area distance in OFT of rats at the end of CUMS. (K) Immobility time in FST of rats at the end of CUMS (n = 10 in NC group, n = 20 in CUMS group). (L) Sucrose preference in SPT of rats at the end of treatment. (M) Central area distance in OFT of rats at the end of treatment. (N) Immobility time in FST of rats at the end of treatment (n = 10/group). Data were shown as the mean ± standard error of mean. The statistical analyses involved the two independent samples t test for comparisons between two groups and one-way analyses of variance alongside the Tukey test for comparisons across multiple groups.
NC, normal control; CUMS, chronic unpredictable mild stress; FLX, fluoxetine; SPT, sucrose preference test; OFT, open field test; TST, tail suspension test; FST, forced swimming test.
*p < 0.05, **p < 0.01.
2024;22:594~609 https://doi.org/10.9758/cpn.24.1167
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