Fig. 1. (A) Brain areas with a significant impact of an interaction between education years and APOE ε4 carrier status on a functional connectivity from seed regions of central executive and dorsal attention network. (B) Relationships of education years to a functional connectivity with regions of interest according to APOE ε4 carrier status. (C) Relationships of a functional connectivity with regions of interest to neuropsychological performance scores in cognitively normal older adults. (A) The color bar on the left corresponds to the Threshold Free Cluster Enhancement score, and the color bar on the right represents the peak F-value. FC, functional connectivity; CEN, central executive network; DAN, dorsal attention network; Rt. DLPFC, right dorsolateral prefrontal cortex; Lt. FEF, left frontal eye field; CERAD-K, Korean version of Consortium to Establish a Registry for Alzheimer’s Disease; TM, sum of the respective scores from the WLM, WLR, and WLRc; Total, sum of all subcategory scores, excluding the MMSE-K and CR scores; ROI, region of interest. (A, B) General linear model adjusting for age, sex, and Aβ retention, ap < 0.05, corrected for multiple comparisons using permutation test; bThresholds were set using GRF correction at a p value of < 0.05, voxel p < 0.001. The statistical threshold of the cluster size > 67. (C) Multiple linear regression analysis adjusting for age, sex, education years, and Aβ retention, Bonferroni corrected p < 0.05.
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