Fig. 1. Experimental procedure. A CD-1 mouse is housed in a compartment separated by a transparent acrylic divider containing many holes: (A) C57BL/6J mouse was transferred from its home cage to the CD-1 home cage; (B) social defeat was observed during 5 minutes; and (C) defeated mouse was separated by the divider for 24 hours. The following day, the C57BL/6J mouse was subjected to social conflict with another CD-1 mouse. This sequence of physical and psychological stress was repeated for 10 days to induce a social defeat model.
SA, social avoidance.
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