Fig. 1. Modulation of PPI and acoustic startle response by clozapine treatment in MIA mice. (A) Startle amplitude was calculated to 120 dB of alone stimuli in all the performed trials. (B) PPI is presented as a mean PPI percentage value in startle amplitude as a function of the magnitude of the prepulse stimulus. (C) Inhibition of startle reflex to a 120 dB stimulus. A stimulus was achieved through prepulse of 71, 74, and 80 dB, corresponding to 3, 6, and 12 dB above the background noise, respectively. PPI, prepulse inhibition; MIA, offspring of mice injected with poly I:C group; MIA ＋ CLZ, clozapine-treated MIA group; CON, control group; CON ＋ CLZ, Clozapine-treated CON group. Data are presented as the mean ± standard error of the mean; *p < 0.05 vs. CON; **p < 0.05 vs. MIA.
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