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Cited by CrossRef (80)

  1. Giles E. Hardingham, Kim Q. Do. Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis. Nat Rev Neurosci 2016;17:125
    https://doi.org/10.1038/nrn.2015.19
  2. Michel Cuenod, Pascal Steullet, Jan-Harry Cabungcal, Daniella Dwir, Ines Khadimallah, Paul Klauser, Philippe Conus, Kim Q. Do. Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia. Mol Psychiatry 2022;27:1886
    https://doi.org/10.1038/s41380-021-01374-w
  3. EricA Klomparens, Yuchuan Ding. The neuroprotective mechanisms and effects of sulforaphane. Brain Circ 2019;5:74
    https://doi.org/10.4103/bc.bc_7_19
  4. Ángel Abellán, Raúl Domínguez-Perles, Diego A. Moreno, Cristina García-Viguera. Sorting out the Value of Cruciferous Sprouts as Sources of Bioactive Compounds for Nutrition and Health. Nutrients 2019;11:429
    https://doi.org/10.3390/nu11020429
  5. Dushani L. Palliyaguru, Jian‐Min Yuan, Thomas W. Kensler, Jed W. Fahey. Isothiocyanates: Translating the Power of Plants to People. Molecular Nutrition Food Res 2018;62
    https://doi.org/10.1002/mnfr.201700965
  6. Tânia Martins, Bruno Colaço, Carlos Venâncio, Maria J Pires, Paula A Oliveira, Eduardo Rosa, Luís M Antunes. Potential effects of sulforaphane to fight obesity. J Sci Food Agric 2018;98:2837
    https://doi.org/10.1002/jsfa.8898
  7. Nora E. Gray, Marcelo Farina, Paolo Tucci, Luciano Saso. The Role of the NRF2 Pathway in Maintaining and Improving Cognitive Function. Biomedicines 2022;10:2043
    https://doi.org/10.3390/biomedicines10082043
  8. Yanli Zhang, Wenyuan Zhang, Yaqi Zhao, Renjie Peng, Zhanquan Zhang, Zhenzhen Xu, Jesus Simal-Gandara, Haixia Yang, Jianjun Deng. Bioactive sulforaphane from cruciferous vegetables: advances in biosynthesis, metabolism, bioavailability, delivery, health benefits, and applications. Critical Reviews in Food Science and Nutrition 2024:1
    https://doi.org/10.1080/10408398.2024.2354937
  9. Wensi Zheng, Xiaolong Li, Tianhong Zhang, Jijun Wang. Biological mechanisms and clinical efficacy of sulforaphane for mental disorders. Gen Psych 2022;35:e100700
    https://doi.org/10.1136/gpsych-2021-100700
  10. Faith Dickerson, Andrea Origoni, Emily Katsafanas, Amalia Squire, Theresa Newman, Jed Fahey, Jian-Chun Xiao, Cassie Stallings, Joshana Goga, Sunil Khushalani, Robert Yolken. Randomized controlled trial of an adjunctive sulforaphane nutraceutical in schizophrenia. Schizophrenia Research 2021;231:142
    https://doi.org/10.1016/j.schres.2021.03.018
  11. Yoko Yagishita, Jed W. Fahey, Albena T. Dinkova-Kostova, Thomas W. Kensler. Broccoli or Sulforaphane: Is It the Source or Dose That Matters?. Molecules 2019;24:3593
    https://doi.org/10.3390/molecules24193593
  12. Alex J. Murray, Jack C. Rogers, Mohammad Zia Ul Haq Katshu, Peter F. Liddle, Rachel Upthegrove. Oxidative Stress and the Pathophysiology and Symptom Profile of Schizophrenia Spectrum Disorders. Front. Psychiatry 2021;12
    https://doi.org/10.3389/fpsyt.2021.703452
  13. Jianfei Zeng, Weizhi Zhang, Xiaobing Lu, Hui Zhou, Jing Huang, Zhenyu Xu, Hairong Liao, Jiaquan Liang, Meihong Liang, Chan Ye, Ting Sun, Yutong Hu, Qi She, Haixia Chen, Qian Guo, LiuJiao Yan, Renrong Wu, Zezhi Li. The association of SOD and HsCRP with the efficacy of sulforaphane in schizophrenia patients with residual negative symptoms. Eur Arch Psychiatry Clin Neurosci 2024;274:1083
    https://doi.org/10.1007/s00406-023-01679-7
  14. Narasimha M. Beeraka, Marco F. Avila-Rodriguez, Gjumrakch Aliev. Recent Reports on Redox Stress-Induced Mitochondrial DNA Variations, Neuroglial Interactions, and NMDA Receptor System in Pathophysiology of Schizophrenia. Mol Neurobiol 2022;59:2472
    https://doi.org/10.1007/s12035-021-02703-4
  15. Benito Soto-Blanco. Herbal Biomolecules in Healthcare Applications. 2022.
    https://doi.org/10.1016/B978-0-323-85852-6.00021-4
  16. Sylvia Maina, Gerald Misinzo, Gaymary Bakari, Ho-Youn Kim. Human, Animal and Plant Health Benefits of Glucosinolates and Strategies for Enhanced Bioactivity: A Systematic Review. Molecules 2020;25:3682
    https://doi.org/10.3390/molecules25163682
  17. Qiongqiong Wu, Xiaoyi Wang, Ying Wang, Yu-Jun Long, Jing-Ping Zhao, Ren-Rong Wu. Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia. Neurosci. Bull. 2021;37:1609
    https://doi.org/10.1007/s12264-021-00740-6
  18. Sébastien Gillotin, Vishal Sahni, Tjaša Lepko, Maya A. Hanspal, Jina E. Swartz, Zoi Alexopoulou, Fiona H. Marshall. Targeting impaired adult hippocampal neurogenesis in ageing by leveraging intrinsic mechanisms regulating Neural Stem Cell activity. Ageing Research Reviews 2021;71:101447
    https://doi.org/10.1016/j.arr.2021.101447
  19. M. López-Moreno, M. Garcés-Rimón, M. Miguel. Antinutrients: Lectins, goitrogens, phytates and oxalates, friends or foe?. Journal of Functional Foods 2022;89:104938
    https://doi.org/10.1016/j.jff.2022.104938
  20. Lena Palaniyappan, Min Tae M. Park, Peter Jeon, Roberto Limongi, Kun Yang, Akira Sawa, Jean Théberge. Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?. Antioxidants 2021;10:1703
    https://doi.org/10.3390/antiox10111703
  21. Yumi Shirai, Yuko Fujita, Ryota Hashimoto, Kazutaka Ohi, Hidenaga Yamamori, Yuka Yasuda, Tamaki Ishima, Hiroyuki Suganuma, Yusuke Ushida, Masatoshi Takeda, Kenji Hashimoto, Kazutaka Ikeda. Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood. PLoS ONE 2015;10:e0127244
    https://doi.org/10.1371/journal.pone.0127244
  22. Víctor Zambrano, Rubén Bustos, Andrea Mahn. Insights about stabilization of sulforaphane through microencapsulation. Heliyon 2019;5:e02951
    https://doi.org/10.1016/j.heliyon.2019.e02951
  23. Shunxi Zhang, Jiahe Zhao, Zhihuai Bai, Lina Luo, Fan Wu, Baolong Li, Yujuan Shan. Sulforaphane inhibits the production of Aβ partially through the activation of Nrf2-regulated oxidative stress. Food Funct. 2021;12:11482
    https://doi.org/10.1039/D1FO02651H
  24. Jiyoung Kim. Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease. IJMS 2021;22:2929
    https://doi.org/10.3390/ijms22062929
  25. Anita A. Panjwani, Hua Liu, Jed W. Fahey. Crucifers and related vegetables and supplements for neurologic disorders. 2018;21:451
    https://doi.org/10.1097/MCO.0000000000000511
  26. Kenji Hashimoto. Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective. Front. Pharmacol. 2018;9
    https://doi.org/10.3389/fphar.2018.01182
  27. Jennifer M. Coughlin, Kun Yang, Anouk Marsman, Subechhya Pradhan, Min Wang, Rebecca E. Ward, Susanne Bonekamp, Emily B. Ambinder, Cecilia P. Higgs, Pearl K. Kim, Jamie A. Edwards, Mark Varvaris, Hongxing Wang, Sotirios Posporelis, Shuangchao Ma, Tsuyoshi Tsujimura, Richard A. E. Edden, Martin G. Pomper, Thomas W. Sedlak, Margot Fournier, David J. Schretlen, Nicola G. Cascella, Peter B. Barker, Akira Sawa. A multimodal approach to studying the relationship between peripheral glutathione, brain glutamate, and cognition in health and in schizophrenia. Mol Psychiatry 2021;26:3502
    https://doi.org/10.1038/s41380-020-00901-5
  28. Ho-Sub Park, Eun-Sang Hwang, Ga-Young Choi, Hyun-Bum Kim, Kyun-Seob Park, Jai-Yoon Sul, Yoonjin Hwang, Geun Wook Choi, Byung Il Kim, Hyunwoo Park, Sungho Maeng, Ji-Ho Park. Sulforaphane enhances long-term potentiation and ameliorate scopolamine-induced memory impairment. Physiology & Behavior 2021;238:113467
    https://doi.org/10.1016/j.physbeh.2021.113467
  29. G. Sh. Burbaeva, T. A. Prokhorova, O. K. Savushkina, E. B. Tereshkina, E. A. Vorobyeva, I. S. Boksha. Oxidative Stress in Schizophrenia: Relation to Neurochemical Pathogenetic Hypotheses. Psychiatry 2024;21:85
    https://doi.org/10.30629/2618-6667-2023-21-6-85-99
  30. Kenji Sanada, Iñaki Zorrilla, Yusuke Iwata, Cristina Bermúdez-Ampudia, Ariel Graff-Guerrero, Mónica Martínez-Cengotitabengoa, Ana González-Pinto. The Efficacy of Non-Pharmacological Interventions on Brain-Derived Neurotrophic Factor in Schizophrenia: A Systematic Review and Meta-Analysis. IJMS 2016;17:1766
    https://doi.org/10.3390/ijms17101766
  31. Mirko Marino, Daniela Martini, Samuele Venturi, Massimiliano Tucci, Marisa Porrini, Patrizia Riso, Cristian Del Bo'. An Overview of Registered Clinical Trials on Glucosinolates and Human Health: The Current Situation. Front. Nutr. 2021;8
    https://doi.org/10.3389/fnut.2021.730906
  32. Yoichiro Takayanagi, Koko Ishizuka, Thomas M. Laursen, Hiroshi Yukitake, Kun Yang, Nicola G. Cascella, Shuhei Ueda, Akiko Sumitomo, Zui Narita, Yasue Horiuchi, Minae Niwa, Akiko Taguchi, Morris F. White, William W. Eaton, Preben B. Mortensen, Takeshi Sakurai, Akira Sawa. From population to neuron: exploring common mediators for metabolic problems and mental illnesses. Mol Psychiatry 2021;26:3931
    https://doi.org/10.1038/s41380-020-00939-5
  33. Vikas Menon, Ilambaridhi Balasubramanian, Ravi Philip Rajkumar. Association between Markers of Oxidative Stress and Cognitive Functioning in Schizophrenia. 2022;6:304
    https://doi.org/10.4103/aip.aip_174_22
  34. Ronald G. Udasin, Xia Wen, Kristin M. Bircsak, Lauren M. Aleksunes, Michael P. Shakarjian, Ah-Ng Tony Kong, Diane E. Heck, Debra L. Laskin, Jeffrey D. Laskin. Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1). Toxicol. Sci. 2016;149:202
    https://doi.org/10.1093/toxsci/kfv226
  35. Zheng Xu, Shudong Wang, Honglei Ji, Zhiguo Zhang, Jing Chen, Yi Tan, Kupper Wintergerst, Yang Zheng, Jian Sun, Lu Cai. Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice. Sci Rep 2016;6
    https://doi.org/10.1038/srep30252
  36. Ce Chen, Wen-hui Jiang, Wei Wang, Xian-cang Ma, Ye Li, Jin Wu, Kenji Hashimoto, Cheng-ge Gao, Hidenori Yamasue. Impaired visual, working, and verbal memory in first-episode, drug-naive patients with major depressive disorder in a Chinese population. PLoS ONE 2018;13:e0196023
    https://doi.org/10.1371/journal.pone.0196023
  37. Yohannes Gebreegziabhere, Kassahun Habatmu, Matteo Cella, Atalay Alem. Development and Evaluation of a Cognitive Battery for People With Schizophrenia in Ethiopia. 2024;50:931
    https://doi.org/10.1093/schbul/sbad178
  38. Ji-chun Zhang, Wei Yao, Chao Dong, Chun Yang, Qian Ren, Min Ma, Mei Han, Jin Wu, Yusuke Ushida, Hiroyuki Suganuma, Kenji Hashimoto. Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation. The Journal of Nutritional Biochemistry 2017;39:134
    https://doi.org/10.1016/j.jnutbio.2016.10.004
  39. Antonio Costa-Pérez, Vanesa Núñez-Gómez, Nieves Baenas, Giuseppe Di Pede, Mariem Achour, Claudine Manach, Pedro Mena, Daniele Del Rio, Cristina García-Viguera, Diego A. Moreno, Raúl Domínguez-Perles. Systematic Review on the Metabolic Interest of Glucosinolates and Their Bioactive Derivatives for Human Health. Nutrients 2023;15:1424
    https://doi.org/10.3390/nu15061424
  40. Chao Huang, Jingjing Wu, Dongjian Chen, Jie Jin, Yue Wu, Zhuo Chen. Effects of sulforaphane in the central nervous system. European Journal of Pharmacology 2019;853:153
    https://doi.org/10.1016/j.ejphar.2019.03.010
  41. A. G. Langston-Cox, D. Anderson, D. J. Creek, K. R. Palmer, S. A. Marshall, E. M. Wallace. Sulforaphane Bioavailability and Effects on Blood Pressure in Women with Pregnancy Hypertension. Reprod. Sci. 2021;28:1489
    https://doi.org/10.1007/s43032-020-00439-5
  42. Jed W. Fahey, Thomas W. Kensler. The Challenges of Designing and Implementing Clinical Trials With Broccoli Sprouts… and Turning Evidence Into Public Health Action. Front. Nutr. 2021;8
    https://doi.org/10.3389/fnut.2021.648788
  43. Jisung Kim, Siyoung Lee, Bo‐Ryoung Choi, Hee Yang, Youjin Hwang, Jung Han Yoon Park, Frank M. LaFerla, Jung‐Soo Han, Ki Won Lee, Jiyoung Kim. Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways. Molecular Nutrition Food Res 2017;61
    https://doi.org/10.1002/mnfr.201600194
  44. Fangkun Liu, Jing Huang, Gangrui Hei, Renrong Wu, Zhixiong Liu. Effects of sulforaphane on cognitive function in patients with frontal brain damage: study protocol for a randomised controlled trial. BMJ Open 2020;10:e037543
    https://doi.org/10.1136/bmjopen-2020-037543
  45. Albena T. Dinkova-Kostova, Jed W. Fahey, Rumen V. Kostov, Thomas W. Kensler. KEAP1 and done? Targeting the NRF2 pathway with sulforaphane. Trends in Food Science & Technology 2017;69:257
    https://doi.org/10.1016/j.tifs.2017.02.002
  46. Yan Wei, Lijia Chang, Guoqi Liu, Xingming Wang, Yong Yang, Kenji Hashimoto. Long-lasting beneficial effects of maternal intake of sulforaphane glucosinolate on gut microbiota in adult offspring. The Journal of Nutritional Biochemistry 2022;109:109098
    https://doi.org/10.1016/j.jnutbio.2022.109098
  47. Fatemeh Ghazizadeh‐Hashemi, Sayna Bagheri, Amir Ashraf‐Ganjouei, Kamyar Moradi, Nazila Shahmansouri, Maryam Mehrpooya, Ahmad‐Ali Noorbala, Shahin Akhondzadeh. Efficacy and safety of sulforaphane for treatment of mild to moderate depression in patients with history of cardiac interventions: A randomized, double‐blind, placebo‐controlled clinical trial. Psychiatry Clin Neurosci 2021;75:250
    https://doi.org/10.1111/pcn.13276
  48. Л.Н. Пороховник, В.М. Писарев. СВЯЗЬ АЛЛЕЛЬНЫХ ВАРИАНТОВ ГЕНА ТРАНСКРИПЦИОННОГО ФАКТОРА Nrf2 С ПАТОГЕНЕЗОМ МНОГОФАКТОРНЫХ ЗАБОЛЕВАНИЙ, "Генетика". Генетика 2017:895
    https://doi.org/10.7868/S0016675817080057
  49. Matthew Dodson, Montserrat Rojo de la Vega, Aram B. Cholanians, Cody J. Schmidlin, Eli Chapman, Donna D. Zhang. Modulating NRF2 in Disease: Timing Is Everything. Annu. Rev. Pharmacol. Toxicol. 2019;59:555
    https://doi.org/10.1146/annurev-pharmtox-010818-021856
  50. Qiongqiong Wu, Jing Huang, Renrong Wu. Drugs Based on NMDAR Hypofunction Hypothesis in Schizophrenia. Front. Neurosci. 2021;15
    https://doi.org/10.3389/fnins.2021.641047
  51. Poonam Sharma, Kanishk Luhach, Neerupma Dhiman, Rajendra Awasthi, Harsha Kharkwal, G.T. Kulkarni, Bhupesh Sharma. Natural Molecules in Neuroprotection and Neurotoxicity. 2021.
    https://doi.org/10.1016/B978-0-443-23763-8.00053-1
  52. Jingmei Xiao, Jing Huang, Yujun Long, Xiaoyi Wang, Ying Wang, Ye Yang, Gangrui Hei, Mengxi Sun, Jin Zhao, Li Li, Tiannan Shao, Weiyan Wang, Dongyu Kang, Chenchen Liu, Peng Xie, Yuyan Huang, Renrong Wu, Jingping Zhao. Optimizing and Individualizing the Pharmacological Treatment of First-Episode Schizophrenic Patients: Study Protocol for a Multicenter Clinical Trial. Front. Psychiatry 2021;12
    https://doi.org/10.3389/fpsyt.2021.611070
  53. Luis Aurelio Montoya-Inzunza, Cristina A. Elizalde-Romero, Manuel A. Picos-Salas, J. Basilio Heredia, Erick P. Gutiérrez-Grijalva. Phytochemical Nanodelivery Systems as Potential Biopharmaceuticals. 2021.
    https://doi.org/10.1016/B978-0-323-90390-5.00010-4
  54. Edward Caddye, Julien Pineau, Joshua Reyniers, Itamar Ronen, Alessandro Colasanti. Lactate: A Theranostic Biomarker for Metabolic Psychiatry?. Antioxidants 2023;12:1656
    https://doi.org/10.3390/antiox12091656
  55. Siyoung Lee, Bo‐Ryoung Choi, Jisung Kim, Frank M. LaFerla, Jung Han Yoon Park, Jung‐Soo Han, Ki Won Lee, Jiyoung Kim. Sulforaphane Upregulates the Heat Shock Protein Co‐Chaperone CHIP and Clears Amyloid‐β and Tau in a Mouse Model of Alzheimer's Disease. Molecular Nutrition Food Res 2018;62
    https://doi.org/10.1002/mnfr.201800240
  56. Evgeny A. Ermakov, Elena M. Dmitrieva, Daria A. Parshukova, Daria V. Kazantseva, Alisa R. Vasilieva, Liudmila P. Smirnova, Karolina Szewczyk-Golec. Oxidative Stress‐Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives. Oxidative Medicine and Cellular Longevity 2021;2021
    https://doi.org/10.1155/2021/8881770
  57. Rui Nouchi, Qingqiang Hu, Yusuke Ushida, Hiroyuki Suganuma, Ryuta Kawashima. Effects of sulforaphane intake on processing speed and negative moods in healthy older adults: Evidence from a randomized controlled trial. Front. Aging Neurosci. 2022;14
    https://doi.org/10.3389/fnagi.2022.929628
  58. Alena Vanduchova, Pavel Anzenbacher, Eva Anzenbacherova. Isothiocyanate from Broccoli, Sulforaphane, and Its Properties. Journal of Medicinal Food 2019;22:121
    https://doi.org/10.1089/jmf.2018.0024
  59. L. N. Porokhovnik, V. M. Pisarev. Association of polymorphisms in NFE2L2 gene encoding transcription factor Nrf2 with multifactorial diseases. Russ J Genet 2017;53:851
    https://doi.org/10.1134/S1022795417080051
  60. Bijal Patel, Giovanni E. Mann, Sarah J. Chapple. Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome. Free Radical Biology and Medicine 2018;122:150
    https://doi.org/10.1016/j.freeradbiomed.2018.02.004
  61. V. Thao-Vi Dao, Ana I. Casas, Ghassan J. Maghzal, Tamara Seredenina, Nina Kaludercic, Natalia Robledinos-Anton, Fabio Di Lisa, Roland Stocker, Pietro Ghezzi, Vincent Jaquet, Antonio Cuadrado, Harald H.H.W. Schmidt. Pharmacology and Clinical Drug Candidates in Redox Medicine. Antioxidants & Redox Signaling 2015;23:1113
    https://doi.org/10.1089/ars.2015.6430
  62. Rui Nouchi, Qingqiang Hu, Toshiki Saito, Natasha Yuriko dos Santos Kawata, Haruka Nouchi, Ryuta Kawashima. Brain Training and Sulforaphane Intake Interventions Separately Improve Cognitive Performance in Healthy Older Adults, Whereas a Combination of These Interventions Does Not Have More Beneficial Effects: Evidence from a Randomized Controlled Trial. Nutrients 2021;13:352
    https://doi.org/10.3390/nu13020352
  63. Thomas W. Sedlak, Leslie G. Nucifora, Minori Koga, Lindsay S. Shaffer, Cecilia Higgs, Teppei Tanaka, Anna M. Wang, Jennifer M. Coughlin, Peter B. Barker, Jed W. Fahey, Akira Sawa. Sulforaphane Augments Glutathione and Influences Brain Metabolites in Human Subjects: A Clinical Pilot Study. Complex Psychiatry 2017;3:214
    https://doi.org/10.1159/000487639
  64. Ramakrishna Kakarla, Praditha Karuturi, Queen Siakabinga, Matte Kasi Viswanath, Naresh Dumala, Chakravarthi Guntupalli, Buchi N. Nalluri, Kojja Venkateswarlu, Vani Sai Prasanna, Gopichand Gutti, Ganesh Yadagiri, Lohitha Gujjari. Current understanding and future directions of cruciferous vegetables and their phytochemicals to combat neurological diseases. Phytotherapy Research 2024;38:1381
    https://doi.org/10.1002/ptr.8122
  65. Wei Yao, Ji-chun Zhang, Tamaki Ishima, Chao Dong, Chun Yang, Qian Ren, Min Ma, Mei Han, Jin Wu, Hiroyuki Suganuma, Yusuke Ushida, Masayuki Yamamoto, Kenji Hashimoto. Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice. Sci Rep 2016;6
    https://doi.org/10.1038/srep30659
  66. Antonia Wiegering, Ulrich Rüther, Christoph Gerhardt. The ciliary protein Rpgrip1l in development and disease. Developmental Biology 2018;442:60
    https://doi.org/10.1016/j.ydbio.2018.07.024
  67. Jiaying Wu, Shumao Cui, Junsheng Liu, Xin Tang, Jianxin Zhao, Hao Zhang, Bingyong Mao, Wei Chen. The recent advances of glucosinolates and their metabolites: Metabolism, physiological functions and potential application strategies. Critical Reviews in Food Science and Nutrition 2023;63:4217
    https://doi.org/10.1080/10408398.2022.2059441
  68. Ji-chun Zhang, Wei Yao, Chao Dong, Mei Han, Yukihiko Shirayama, Kenji Hashimoto. Keap1–Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress. Eur Arch Psychiatry Clin Neurosci 2018;268:865
    https://doi.org/10.1007/s00406-017-0848-0
  69. Kazuki Terada, Ayumi Murata, Erina Toki, Shotaro Goto, Hirofumi Yamakawa, Shuichi Setoguchi, Daisuke Watase, Mitsuhisa Koga, Jiro Takata, Kazuhisa Matsunaga, Yoshiharu Karube. Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study. Molecules 2020;25:4206
    https://doi.org/10.3390/molecules25184206
  70. Yoko Yagishita, Tonibelle N. Gatbonton-Schwager, Melissa L. McCallum, Thomas W. Kensler. Current Landscape of NRF2 Biomarkers in Clinical Trials. Antioxidants 2020;9:716
    https://doi.org/10.3390/antiox9080716
  71. Jie Gao, Bingrui Xiong, Bo Zhang, Shan Li, Niannian Huang, Gaofeng Zhan, Riyue Jiang, Ling Yang, Yeshun Wu, Liying Miao, Bin Zhu, Chun Yang, Ailin Luo. Sulforaphane Alleviates Lipopolysaccharide-induced Spatial Learning and Memory Dysfunction in Mice: The Role of BDNF-mTOR Signaling Pathway. Neuroscience 2018;388:357
    https://doi.org/10.1016/j.neuroscience.2018.07.052
  72. Maria Teresa Bayo Jimenez, Katie Frenis, Omar Hahad, Sebastian Steven, Guy Cohen, Antonio Cuadrado, Thomas Münzel, Andreas Daiber. Protective actions of nuclear factor erythroid 2-related factor 2 (NRF2) and downstream pathways against environmental stressors. Free Radical Biology and Medicine 2022;187:72
    https://doi.org/10.1016/j.freeradbiomed.2022.05.016
  73. Paolo Tucci, Maria Bove, Vladyslav Sikora, Stefania Dimonte, Maria Grazia Morgese, Stefania Schiavone, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Luigia Trabace. Glucoraphanin Triggers Rapid Antidepressant Responses in a Rat Model of Beta Amyloid-Induced Depressive-like Behaviour. Pharmaceuticals 2022;15:1054
    https://doi.org/10.3390/ph15091054
  74. Qian Chen, Ting Cao, NaNa Li, Cuirong Zeng, Shuangyang Zhang, Xiangxin Wu, Bikui Zhang, Hualin Cai. Repurposing of Anti-Diabetic Agents as a New Opportunity to Alleviate Cognitive Impairment in Neurodegenerative and Neuropsychiatric Disorders. Front. Pharmacol. 2021;12
    https://doi.org/10.3389/fphar.2021.667874
  75. Gangrui Hei, Robert C Smith, Ranran Li, Jianjun Ou, Xueqing Song, Yingjun Zheng, Yiqun He, Jen Arriaza, Jed W Fahey, Brian Cornblatt, Dongyu Kang, Ye Yang, Jing Huang, Xiaoyi Wang, Kristin Cadenhead, Mimei Zhang, John M Davis, Jingping Zhao, Hua Jin, Renrong Wu. Sulforaphane Effects on Cognition and Symptoms in First and Early Episode Schizophrenia: A Randomized Double-Blind Trial. 2022;3
    https://doi.org/10.1093/schizbullopen/sgac024
  76. Ali Shah, Manasi Varma, Ranjana Bhandari. Exploring sulforaphane as neurotherapeutic: targeting Nrf2-Keap & Nf-Kb pathway crosstalk in ASD. Metab Brain Dis 2023;39:373
    https://doi.org/10.1007/s11011-023-01224-4
  77. Emma L. Connolly, Marc Sim, Nikolaj Travica, Wolfgang Marx, Gemma Beasy, Gordon S. Lynch, Catherine P. Bondonno, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst. Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence. Front. Pharmacol. 2021;12
    https://doi.org/10.3389/fphar.2021.767975
  78. Congchong Wu, Xingyang Chen, Jianbo Lai, Yi Xu, Shaohua Hu. The efficacy and safety of sulforaphane as an adjuvant in the treatment of bipolar depressive disorder. 2020;99:e20981
    https://doi.org/10.1097/MD.0000000000020981
  79. Poonam Sharma, Prachi Kaushik, Swati Jain, Brij Mohan Sharma, Rajendra Awasthi, Giriraj Thirupathirao Kulkarni, Bhupesh Sharma. Efficacy of Ulinastatin and Sulforaphane Alone or in Combination in Rat Model of Streptozotocin Diabetes Induced Vascular Dementia. Clin Psychopharmacol Neurosci 2021;19:470
    https://doi.org/10.9758/cpn.2021.19.3.470
  80. Ravi Kumar, Tristan de Mooij, Timothy E. Peterson, Tatiana Kaptzan, Aaron J. Johnson, David J. Daniels, Ian F. Parney, Anita B. Hjelmeland. Modulating glioma-mediated myeloid-derived suppressor cell development with sulforaphane. PLoS ONE 2017;12:e0179012
    https://doi.org/10.1371/journal.pone.0179012