Acceptance of the deltoid muscle injection of aripiprazole long-acting injectable in the patients with schizophrenia
Hiroyuki Kamei 1, 6*, Yuki Homma 1, Ippei Takeuchi 3, 3, Genta Hajitsu 4, Kaori Tozawa 5, Masakazu Hatano 1, 2, 6, Aiko Fukui 1, Manako Hanya 1, Shigeki Yamada 2, Nakao Iwata 6
1Office of Clinical Pharmacy Practice and Health Care Management, Faculty of Pharmacy, Meijo University, 2Department of Clinical Pharmacy, Fujita Health University School of Medicine, 3Department of Psychiatry, Okehazama Hospital, 4Department of Psychiatry, Kamibayashi Memorial Hospital, 5Department of Psychiatry, Kyowa Hospital, 6Department of Psychiatry, Fujita Health University School of Medicine
Received: June 1, 2019; Revised: August 2, 2019; Accepted: August 31, 2019; Published online: August 31, 2019.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: To improve poor medication adherence in schizophrenic patients, long-acting injectable (LAI) antipsychotics are used. However, it has not yet become common in Japan. Recently, aripiprazole LAI was approved for alternative injection into the deltoid muscle in addition to the gluteal muscle. The acceptance for the proposal to switch from gluteal to deltoid injections of aripiprazole LAI was investigated.
Methods: The subjects were 32 outpatients with schizophrenia who had continuously received aripiprazole LAI administration into the gluteal muscle for ≥6 months. In the patients who had continued deltoid injection for 3 months after switching, the changes in the pain and shame in comparison with gluteal injections were evaluated.
Results: Switching to the deltoid injection was chosen by 17 out of 32 patients. Three months later, 9 patients were still receiving deltoid injections with highly rated satisfaction. The main reasons for switching to deltoid injections included the pain and shame associated with gluteal injections. The main reason for returning to the gluteal injection was the pain experienced from the injection in the deltoid.
Conclusion: The option to select the injected area was based on the amount of pain in the deltoid and gluteal sites, leading to the widespread use of aripiprazole LAI.
Keywords: Aripiprazole, Antipsychotic, Antipsychotic, Schizophrenia, Long-acting injection, Gluteal, Schizophrenia, Deltoid, Gluteal


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