Altered Auditory P300 Performance in Parents with Attention-deficit Hyperactivity Disorder Offspring
Mei Hung Chi 1, Ching-Lin Chu 1, I Hui Lee 1, Yi-Ting Hsieh 1, Ko Chin Chen 1, Po See Chen 1, Yen-Kuang Yang 1*
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Received: January 21, 2019; Revised: June 21, 2019; Accepted: June 23, 2019; Published online: June 23, 2019.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: Altered event-related potential (ERP) performances have been noted in attention-deficit hyperactivity disorder (ADHD) patients and reflect neurocognitive dysfunction. Whether these ERP alterations and correlated dysfunctions exist in healthy parents with ADHD offspring is worth exploring.
Methods: Thirteen healthy parents with ADHD offspring and thirteen healthy controls matched for age, sex and years of education were recruited. The auditory oddball paradigm was used to evaluate the P300 wave complex of the ERP, and the Wechsler Adult Intelligence Scale-Revised, Wisconsin Card Sorting Test, and Continuous Performance Test were used to measure neurocognitive performance.
Results: Healthy parents with ADHD offspring had significantly longer auditory P300 latency at Fz than control group. However, no significant differences were found in cognitive performance.
Conclusion: The presence of a subtle alteration in electro-neurophysiological activity without explicit neurocognitive dysfunction suggests potential candidate of biological marker for parents with ADHD offspring.
Keywords: attention-deficit hyperactivity disorder, cognition, event-related potential, P300, parents


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