Determination of Serum Vascular Endothelial Growth Factor (VEGF) Levels in Attention Deficit Hyperactivity Disorder: A Case Control Study
yasemin tas torun *, esra guney 2, arzu aral 3, dicle buyuktaskin 2, huseyin tunca 4, yasemen isik 2, elvan iseri 2
1Gulhane Education and Training Hospital, Child and Adolescent Psychiatry Department, Ankara, Turkey , 2Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey., 3Gazi University Medical Faculty, Department of Immunology, Ankara, Turkey, 4Diyarbakır Education and Training Hospital, Child and Adolescent Psychiatry Department, Diyarbakır, Turkey
Received: January 31, 2019; Revised: June 11, 2019; Accepted: June 19, 2019; Published online: June 19, 2019.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective
The effect of VEGF on neuronal development is known, but its relationship with ADHD, a neurodevelopmental disorder, has not yet been fully elucidated. To our knowledge, this is the first human study investigating serum VEGF levels in ADHD patients. In this study, it has been aimed to compare serum VEGF levels between a healthy control group and in ADHD patients to help determine the association between serum VEGF levels and ADHD.
Methods
This study sample included forty-four patients diagnosed with ADHD and 43 healthy volunteer controls between 7-14 years old. Blood samples were taken from patients and the healthy control group to assess their serum VEGF levels. The samples were analyzed in a single session without designating whether they were from the control or the patient group. VEGF levels were calculated by subjecting the optical densities of the samples to concentrations of known standards as provided in the ELISA kit and then performing a regression correlation analysis.
Results
The mean VEGF level of the children was 333.6 ± 209.8 in the ADHD group and 341.3 ± 201.8 in the control group. There were no statistically significant differences in serum VEGF levels between the ADHD and control groups (U=926.000, z=-0.170, p=0.865).
Conclusion
There was no significant difference in serum VEGF levels for untreated ADHD cases and a healthy control group. This is the first human study investigating serum VEGF levels in ADHD patients, so there is a need to replicate these findings.
Keywords: VEGF, ADHD, ADHD, CHILDREN


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