Clin Psychopharmacol Neurosci 2019; 17(2): 308-313  
Effect of Maternal Depression on Brain-derived Neurotrophic Factor Levels in Fetal Cord Blood
Erdem Onder Sonmez1, Faruk Uguz2, Mine Sahingoz2, Gulsum Sonmez3, Nazmiye Kaya2, Mehmet Akif Camkurt4, Zeynel Gokmen5, Mustafa Basaran6, Kazim Gezginc7, Sami Sait Erdem8, Hasan Haluk Dulger9, Erkan Tasyurek9
1Department of Psychiatry, Dr. Ekrem Tok Mental Health and Disease Hospital, Adana, 2Department of Psychiatry, 7Department of Obstetrics and Gynecology, 9Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, 3Department of Pediatrics, Çukurova University, Adana, 4Department of Psychiatry, Afşin State Hospital, Kahramanmaras, 5Department of Neonatology, 6Department of Obstetrics and Gynecology, 8Department of Biochemistry, Konya Research and Training Hospital, Konya, Turkey
Correspondence to: Erdem Onder Sonmez, MD Department of Psychiatry, Dr. Ekrem Tok Mental Health and Disease Hospital, Adana 01500, Turkey
Tel: +90-505-3834585, Fax: +90-344-5112966 E-mail: eondersonmez@gmail.com
ORCID: https://orcid.org/0000-0002-1647-6287
Received: April 12, 2016; Revised: May 27, 2016; Accepted: June 16, 2016; Published online: May 31, 2019.
© The Korean College of Neuropsychopharmacology. All rights reserved.

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objective: We aimed to assess the association between cord blood brain-derived neurotrophic factor (BDNF) concentration and maternal depression during pregnancy.
Methods: A total of 48 pregnant women, admitted for elective caesarean section to Department of Obstetrics and Gynecology, The Konya Research and Training Hospital and Konya Necmettin Erbakan University Meram Medical Faculty, were included in this study. The study group included 23 women diagnosed as having depression during pregnancy and the control group included 25 pregnant women who did not experience depression during pregnancy.
Results: The groups had similar sociodemographic characteristics. Cord blood BDNF concentration was significantly lower in babies born to mothers with major depression as compared with those in the control group. We didn’t find any correlation between the umbilical cord blood BDNF levels and BDI scores.
Conclusion: The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels.
Keywords: Brain-derived neurotrophic factor; Pregnancy; Depression; Fetal cord blood; Neurodevelopment.


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