Clin Psychopharmacol Neurosci 2019; 17(2): 170-182  
Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications
Rujuta Parlikar*, Anushree Bose*, Ganesan Venkatasubramanian
WISER Program, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
Correspondence to: Ganesan Venkatasubramanian, MD, PhD, WISER Neuromodulation Program, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bengaluru 560029, Karnataka, India
Tel: +91-80-26995256, Fax: +91-80-26564830 E-mail: gvs@nimhans.ac.in
ORCID: https://orcid.org/0000-0002-0949-898X
*These authors contributed equally to this study as co-first authors.
Received: June 7, 2018; Revised: July 25, 2018; Accepted: August 2, 2018; Published online: May 31, 2019.
© The Korean College of Neuropsychopharmacology. All rights reserved.

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Corollary discharge mechanism refers to the suppression of sensory consequences of self-generated actions; a process that serves to distinguish between self and non-self based on discrimination of origination of action. It explains, say for example, why we cannot tickle ourselves. This review discusses how corollary discharge model is an essential neural integration mechanism central to the motor functioning of animal kingdom. In this article, research conducted in the field of corollary discharge has been reviewed to understand the neuroanatomical and neurophysiological basis of corollary discharge and gain insight into the biochemical basis of its dysfunction. This review article also explores the role of corollary discharge and its dysfunction in the presentation of symptoms of schizophrenia, discussing the findings from corollary discharge studies on schizophrenia population. Lastly, the link between schizophrenia psychopathology and corollary discharge dysfunction has been highlighted, and an attempt has been made to establish a case for correction of corollary discharge deficit in schizophrenia through neuromodulation.
Keywords: Corollary discharge; Efference copy; Motor activity; Auditory hallucination; Transcranial direct current stimulation.


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