The efficacy of miniaturized repetitive transcranial magnetic stimulation in patients with depression
Sangmin Lee 1, 2, Kuk-In Jang 1, 2, Sejin Yoon 4, Jeong-Ho Chae 1, 2, 3*
1Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea, 2Institute of Biomedical Industry, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea, 3Department of Psychiatry, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea, 4REMED Co., Ltd. 301~303, Migun Techno World II, 187, Techno 2-ro, Yuseong-gu, Daejeon, Republic of Korea
Received: August 14, 2018; Revised: October 29, 2018; Accepted: November 30, 2018; Published online: November 30, 2018.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: The present study aimed to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) at a high frequency using a miniaturized device compared to standard rTMS and sham rTMS for the treatment of depression.
Methods: Fifty-four patients with depression were randomly assigned to either 15 days of miniaturized, standard, or sham rTMS. The stimulation consisted of 60 trains of 5 s at 10 Hz for 30 min. Clinical measures were assessed at baseline and on the final day of the stimulation.
Results: A repeated-measures analysis of variance revealed a significant main effect of time and a time by group interaction on Hamilton Rating Scale for Depression scores. There were no significant correlations between individual motor thresholds and changes of clinical outcomes. Our results revealed a significant reduction in the Hamilton Rating Scale for Depression in the miniaturized and standard groups compared to the sham group.
Conclusion: The antidepressant utility of miniaturized rTMS using subthreshold stimulation was comparable to that of standard stimulation.
Keywords: depression, transcranial magnetic stimulation, antidepressants


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