Ramelteon for delayed sleep-wake phase disorder: A case report
Masahiro Takeshima 1*, Tetsuo Shimizu 2, Hiroyasu Ishikawa 3, Takashi Kanbayashi 1
1Akita University Graduate School of Medicine, 2Mental Health and Welfare Center, 3Nakadori Rehabilitation Hospital
Received: July 11, 2018; Revised: September 18, 2018; Accepted: October 26, 2018; Published online: October 26, 2018.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Recently developed melatonin receptor agonists are expected to be effective for delayed sleep-wake phase disorder (DSWPD). To date, however, no study has described the effect of melatonin receptor agonists on DSWPD. We report the case of a 15-year-old girl with DSWPD who was successfully treated with ramelteon 4 mg at 7 PM. DSWPD symptoms were resolved; her sleep-wake and biological rhythms were normalized.
Keywords: circadian rhythm sleep disorders, delayed sleep phase syndrome, melatonin agonist, ramelteon, sleep disorders