Clin Psychopharmacol Neurosci 2018; 16(3): 343-345  
Amenorrhea as a Side Effect of Low Dose Aripiprazole: An Adolescent Case
Gulen Guler1, Meryem Ozlem Kutuk2, Halil Kara3
1Department of Child and Adolescent Psychiatry, Elazig Mental Health Hospital, Elazig, 2Department of Child and Adolescent Psychiatry, Baskent University Medical Faculty, Adana, 3Department of Child and Adolescent Psychiatry, Aksaray State Hospital, Aksaray, Turkey
Correspondence to: Gulen Guler, MD
Department of Child and Adolescent Psychiatry, Elazig Mental Health Hospital, Rizaiye Mah, Kazım Hoca Street No: 23/B, Elazig 23100, Turkey
Tel: +90-424-238-79-53, Fax: +90-424-212-78-31
Received: December 21, 2016; Revised: December 30, 2016; Accepted: December 31, 2016; Published online: August 31, 2018.
© The Korean College of Neuropsychopharmacology. All rights reserved.

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Amenorrhea, oligomenorrhea, galactorrhoea, gynecomastia, infertility, and sexual dysfunction may arise as a consequence of hyperprolactinemia. Hyperprolactinemia is one of major side effects of treatment with antipsychotics, but aripiprazole is known as a dopamine stabilizer antipsychotic which can be used to improve hyperprolactinemia. In this report, it was described that an adolescent patient experienced amenorrhea after adding very low dose aripiprazole to ongoing fluoxetine treatment regime for major depressive disorder. Additionally, this case showed that the patient recovered from the amenorrhea with replacement of aripiprazole with quetiapine.
Keywords: Adolescent; Amenorrhea; Aripiprazole.

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