Clin Psychopharmacol Neurosci 2018; 16(3): 339-342  
The Effects of Continuation-Maintenance Electroconvulsive Therapy on Reducing Hospital Re-Admissions in Patients with Treatment-Resistant Schizophrenia
Kyung Mook Choi1,*, Soo-Hee Choi1,2,*, Jung Kyung Hong1, Mi Hyun Lee1, Joon Hyung Jung1, Sang Hoon Oh1, Dong Chung Jung1, Sung Nyun Kim1
1Department of Neuropsychiatry, Seoul National University Hospital, 2Department of Psychiatry and Institute of Human Behavioral Sciences, Seoul National University College of Medicine, Seoul, Korea
Correspondence to: Sung Nyun Kim, MD, PhD
Department of Neuropsychiatry, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea
Tel: +82-2-2072-4930, Fax: +82-2-744-7241
*These authors contributed equally to this study as co-first authors.
Received: May 25, 2017; Revised: May 26, 2017; Accepted: May 29, 2017; Published online: August 31, 2018.
© The Korean College of Neuropsychopharmacology. All rights reserved.

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective: Continuation-maintenance electroconvulsive therapy (C/M-ECT) is used to prevent relapse or recurrence in patients with severe mental illnesses. We aimed to investigate the effect of C/M-ECT on reducing hospital re-admissions in patients with treatment-resistant schizophrenia.
Methods: We applied a mirror-image design by retrospectively examining re-hospitalization rates of 18 patients with schizophrenia spectrum disorders. We compared the numbers of psychiatric admissions during the actual period over which C/M-ECT was administered with the same period prior to the beginning of C/M-ECT.
Results: The number of psychiatric admissions was reduced significantly during C/M-ECT (0.33±0.77) compared with that of the same period prior to C/M-ECT (2.67±1.33) (Wilcoxon signed rank Z=−3.663; p<0.001).
Conclusion: This finding shows that C/M-ECT augmentation could successfully reduce the re-hospitalization rates in patients with treatment-resistant schizophrenia.
Keywords: Electroconvulsive therapy; Schizophrenia; Treatment-resistance; Recurrence; Hospitalization.

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