Clin Psychopharmacol Neurosci 2018; 16(3): 302-309  
Depressive Temperament in Relatives of Patients with Schizophrenia Is Associated with Suicidality in Patients with Schizophrenia
Esra Yazici1, Zerrin Cimen2, Ipen Ilknur Unlu Akyollu2, Ahmet Bulent Yazici2, Betul Aslan Turkmen2, Atila Erol1
1Department of Psychiatry, Faculty of Medicine, Sakarya University, 2Department of Psychiatry, Sakarya University Training and Research Hospital, Sakarya, Turkey
Correspondence to: Ahmet Bulent Yazici, MD
Department of Psychiatry, Sakarya University Training and Research Hospital, Sakarya 54290, Turkey
Tel: +90-5325994988, Fax: +90-264-2552105
E-mail: a.bulentyaz@gmail.com
ORCID: https://orcid.org/0000-0001-5631-3100
Received: May 16, 2017; Revised: July 16, 2017; Accepted: August 11, 2017; Published online: August 31, 2018.
© The Korean College of Neuropsychopharmacology. All rights reserved.

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objective: Suicide is a major cause of death in patients with schizophrenia; thus, predicting and preventing suicide in patients with schizophrenia is examined in various studies. Affective temperaments which are accepted as precursors of mood disorders may be an important factor in predicting suicidality. This study investigated the relationship between affective temperaments of relatives of schizophrenia patients and suicidal thoughts and other clinical correlates of patients with schizophrenia.
Methods: Patients with schizophrenia and their first degree relatives are included to the study. All of the participants were evaluated with Structured Clinical Interview for DSM-IV axis I disorders and relatives with active psychiatric diagnosis were excluded. Positive and Negative Symptom Scale, Clinical Global Impression Scale, Turkish version of cognitive assessment interview were administered congruently to the patients. Relatives of the patients were evaluated with Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Auto-questionnaire.
Results: Depressive temperament scores of relatives of schizophrenic patients who had suicidal thoughts were higher than the scores of the relatives of the patients who did not have suicidal thoughts. Depressive temperament also predicted number of suicide attempts in regression analysis. Number of suicide attempts was also related with number of hospitalization and functionality of the patient.
Conclusion: Suicidality in schizophrenia is related with relatives’ affective temperaments and patients’ own positive symptom scores. The relationship between suicidal thoughts and depressive temperament is high lightened in this study
Keywords: Suicide; Schizophrenia; Family; Temperament; Depressive mood.


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