Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naïve Patients with Major Depression: a study in the “real world” clinical practice
Domenico De Berardis *
NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini”, ASL 4 Teramo, Italy
Received: February 23, 2018; Revised: May 6, 2018; Accepted: June 27, 2018; Published online: June 27, 2018.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Objective: to elucidate relationships between alexithymia, suicide ideation and homocysteine levels in drug-naïve outpatients with Major Depression (MDD)
Methods: 67 outpatients with MDD with melancholic features were evaluated by the means of the Hamilton Depression Rating Scale, the Toronto Alexithymia Scale (TAS–20), the Scale of Suicide Ideation and homocysteine levels.
Results: Alexithymic subjects showed higher scores on all scales and higher homocysteine levels. Regression analysis shown higher homocysteine levels and TAS-20’ “Difficulty in Describing Feelings” dimension, in turn being associated with higher suicide ideation.
Conclusions: In conclusion, alexithymic MDD outpatients may characterize for homocysteine dysregulation that may be linked to suicide ideation, regardless depression’ severity. However, study limitations are discussed and must be considered.
Keywords: Alexithymia, homocysteine, suicide ideation, depression