Clinical Psychopharmacology and Neuroscience 2018; 16(2): 144-152
Diagnostic Validity of an Automated Probabilistic Tractography in Amnestic Mild Cognitive Impairment
Won Sang Jung1, Yoo Hyun Um2, Dong Woo Kang3, Chang Uk Lee3, Young Sup Woo4, Won-Myong Bahk4, and Hyun Kook Lim4
1Department of Radiology, St. Vincent Hospital, Suwon, Korea, 2Department of Psychiatry, St. Vincent Hospital, Suwon, Korea, 3Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, 4Department of Psychiatry, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Correspondence to: Hyun Kook Lim, MD, PhD, Department of Psychiatry, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Tel: +82-2-3779-1048, Fax: +82-2-780-6577, E-mail:, ORCID:
Received: November 7, 2016; Revised: November 15, 2016; Accepted: November 22, 2016; Published online: May 31, 2018.
© The Korean College of Neuropsychopharmacology. All rights reserved.

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although several prior works showed the white matter (WM) integrity changes in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease, it is still unclear the diagnostic accuracy of the WM integrity measurements using diffusion tensor imaging (DTI) in discriminating aMCI from normal controls. The aim of this study is to explore diagnostic validity of whole brain automated probabilistic tractography in discriminating aMCI from normal controls.


One hundred-two subjects (50 aMCI and 52 normal controls) were included and underwent DTI scans. Whole brain WM tracts were reconstructed with automated probabilistic tractography. Fractional anisotropy (FA) and mean diffusivity (MD) values of the memory related WM tracts were measured and compared between the aMCI and the normal control groups. In addition, the diagnostic validities of these WM tracts were evaluated.


Decreased FA and increased MD values of memory related WM tracts were observed in the aMCI group compared with the control group. Among FA and MD value of each tract, the FA value of left cingulum angular bundle showed the highest area under the curve (AUC) of 0.85 with a sensitivity of 88.2%, a specificity of 76.9% in differentiating MCI patients from control subjects. Furthermore, the combination FA values of WM integrity measures of memory related WM tracts showed AUC value of 0.98, a sensitivity of 96%, a specificity of 94.2%.


Our results with good diagnostic validity of WM integrity measurements suggest DTI might be promising neuroimaging tool for early detection of aMCI and AD patients.

Keywords: Mild cognitive impairment, Diffusion tensor imaging, Diffusion tensor imaging, Biomarker

The incidence of dementia and cognitive disorder is increasing.1) Amnestic mild cognitive impairment (aMCI) is a selective decline in memory in the situation of otherwise normal cognition and normal daily functioning.2) The rate of change from MCI to overt dementia is substantial at 10% to 15% per year, the majority of these being Alzheimer’s disease (AD).24) Therapeutic approach for AD is more focused on preventing or delaying of disease onset in preclinical stage.5) Therefore, many investigators are striving to establish efficient biomarkers for early detection of AD for preventive interventions.68)

The diffusion tensor imaging (DTI) is an in vivo magnetic resonance imaging (MRI) technique, which is able to evaluate the microstructural integrity of white matter (WM).9) DTI is a non-invasive imaging method based on the diffusion characteristics of water molecules.10) The results of previous studies about aMCI and AD patients with DTI analysis showed microstructural changes of WM in brain.1115) The majority of findings in previous DTI studies was increased mean diffusivity (MD) and reduced fractional anisotropy (FA) in parietal and temporal lobes, which is located posterior hemispheric WM. Several studies with tractography based analysis more specifically showed WM structural abnormality in the splenium of the corpus callosum, posterior cingulum, uncinate fasciculi.1619) The promising value of DTI as an imaging biomarker for AD and aMCI has been reported. There were a few studies combining DTI and morphometry measures to increase diagnostic performance of aMCI patients.2,20,21) Also, DTI was found to be more sensitive than hippocampal volumetry for distinguishing between aMCI patients and healthy controls.22) In other studies, hippocampal diffusivity was a better predictor than hippocampal volumetry for the conversion from MCI to AD23) and WM integrity change of fornix was the earliest finding of cognitive impairment group in normal controls.24) The results of these studies suggest that alterations of WM integrity can be a useful imaging biomarker for early prediction of cognitive impairment patients.

In previous studies of DTI in AD and aMCI patients, commonly used methodologies were quantitative region-of-interest (ROI) based techniques or a voxel-based analysis (VBA) or quantitative tract-based analysis techniques. The ROI placement by manual drawing method is not precisely reproducible in different cases and time consuming.25,26) The VBA technique using statistical parametric mapping (SPM) has well-known problem of arbitrary spatial smoothing extent, which unavoidably affect the group differences.27) Recently, many DTI studies have applied tract-based spatial statistics (TBSS) in FSL (FMRIB Software Library, software, which can overcome SPM problem, using an algorithm aligns each individuals mean FA to a common standard space in registration process. However, TBSS is more suitable tool for group analysis with carrying out voxelwise statistics across subjects, not convenient to reveal altered WM integrity of individual subject.

The purpose of this study was to investigate the diagnostic accuracy of automated tractography based on DTI for differentiation of aMCI patient from normal control group. We hypothesized diffusion metrics changes more obviously occur at the WM tracts related memory circuit such as inferior longitudinal fasciculus (ILF), cingulum, parietal bundle of superior longitudinal fasciculus, forcep major and minor of corpus callosum.28)



One hundred-two subjects took part in this study (50 with aMCI and 52 healthy elderly controls). They were recruited from the Catholic Geriatric Brain MRI Database which was built through the outpatient geriatric psychiatry clinic of St. Vincent’s Hospital located in Suwon, South Korea from October 2009 to February 2016.

Diagnosis of aMCI was made according to the criteria by Petersen29) including a subjective cognitive complaint (corroborated by an informant), impairment of memory with comprehensive neuropsychological test (<1.5 standard deviation below the performance of age and education control subjects in the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-K) neuropsychological battery30)), normal general cognitive functioning, and preserved instrumental activities of daily living. All aMCI individuals had an overall Clinical Dementia Rating (CDR) score of 0.5.31) Fifty two healthy controls with an overall CDR of 0 were also selected after a standardized clinical assessment and CERAD-K neuropsychological test battery. A clinical neuroradiologist (WSJ) examined the brain MRIs of all the subjects; no gross abnormalities were reported in any participant and showed normal-appearing WM.

All participants gave written informed consent, and the study was approved by the Ethical Committee of the local Institutional Review Board of the Catholic University of Korea (No. VC15EISI0044). All subjects were right-handed.

Magnetic Resonance Imaging Acquisition

All participants underwent MRI scans on a 3-tesla whole body scanner equipped with an 8-channel phased-array head coil (Verio; Siemens, Erlangen, Germany). The scanning parameters of the T1-weighted three-dimensional magnetization-prepared rapid gradient echo sequences were as follows; echo time=2.5 ms, repetition time=1,900 ms, inversion time=900 ms, flip angle=9°, field of view=250×250 mm, matrix=256×256, and voxel size=1.0×1.0×1.0 mm. In addition the scanning parameters of the DTI sequences were as follows; echo planar imaging, TR=9,300 ms, TE=94 ms, field of view=192 mm, voxel dimension=2 mm isotropic, B-value=1,000, gradients applied=30 isotropically, and distributed and acquisition time=21 min.

Image Processing

The workflow of imaging processing can be summarized in five steps.

  • Cortical and subcortical segmentations of structural T1-weighted MRI by automated reconstruction tool of FreeSurfer software (version 5.3.0; The technical details had been well described in previous articles.3234) Briefly, this process consists of a Talairach transform of each subject’s native brain, removal of the skull, and segmentation of the gray and WM tissue. This is fundamental step for addressing specific anatomic parts of each subjects’ brain.

  • Preprocessing of the DTI images. This process includes Eddy-current correction, intra-subject registration (diffusion weighted image to T1 data) by FreeSurfer’s bbregister,35) inter-subject registration of each subject to a common MNI152 template,36) creation of cortical and WM masks from T1 reconstruction data, fitting of diffusion tensors using FSL’s dtifit (, computing anatomical priors for WM pathways from training data.

  • Ball and stick modeling37) of the diffusion data using FSL’s bedpostx tool. This model provides one isotropic diffusion and multiple anisotropic diffusion compartments per voxel, revealing the diffusion data of voxel as a volume and orientations.

  • Automated reconstructing WM pathways. TRACULA (TRActs Constrained by UnderLying Anatomy, was introduced as an automated analyzing method for WM tract evaluation.38) TRACULA utilizes formerly obtained anatomic knowledge from a set of training participants where the WM tracts were labeled manually. This prior information is the probability of each tract to travel through or next to each of the cortical and subcortical segmentation labels from FreeSurfer. Based on this data, TRACULA can reconstruct 18 major WM tracts from local diffusion orientation of each subject’s ball and stick model. The 18 available WMs are corticospinal tract (CST), ILF, uncinate fasciculus, anterior thalamic radiation (ATR), cingulum-cingulate gyrus (supracallosal) bundle (CING), cingulum-angular (infracallosal) bundle (CAB), superior longitudinal fasciculus-parietal bundle (SLFP), superior longitudinal fasciculus-temporal bundle (SLFT), corpus callosum-forceps major (Fmaj), corpus callosum-forceps minor (Fmin). The output of TRACULA is a probabilistic distribution for each of the 18 tracts (Fig. 1).38)

  • Obtaining value of diffusion metrics for statistical analysis. We extracted statistics result files of each WM tracts, containing various diffusion measures such as tract volume, FA, MD. As the motor cortex and related WM tracts are known to be not affected by AD at the earlier stage, the results of both CSTs, well-known WM tract related motor function, were omitted for statistical analysis.

Statistical Analysis

Statistical analyses for demographic data (Table 1) were performed with the Statistical Package for Social Sciences software (version 12.0; SPSS Inc., Chicago, IL, USA). Assumptions for normality were tested for all continuous variables. Normality was tested using the Kolmogorov-Smirnov test. All variables were normally distributed. The independent t-test and the χ2 test were used to assess potential differences between the aMCI groups and healthy control groups for all demographic variables. All statistical analyses had a two-tailed a level of <0.05 for defining statistical significance.

The general linear model was implemented to identify the of 16 WM tracts in which aMCI subjects showed significant differences in mean values of DTI parameters (FA, MD) relative to controls. The effects of age, education, total intracranial volume, and gender were regressed out in these models. The Bonferroni method was used for correction for multiple comparisons. Statistical significance was thresholded at Bonferroni corrected p<0.05.

We performed binary logistic regression with receiver operator characteristic (ROC) analysis to evaluate the sensitivity, specificity, and accuracy of DTI parameters (FA, MD) of each 16 WM tracts to discriminate aMCI from the controls, and predict the aMCI subjects who converted to AD. Area under the curve (AUC) was used to evaluate the optimal cutoff point. A result with p<0.05 and AUC value >0.5 were considered statistically significant and diagnostically meaningful. We also calculated the specificity and sensitivity of each DTI parameters of ‘combined’ measurements of previously known memory related circuits (Fmaj, CAB, CING, SLFP, and ILF)28,39) were indicated by areas under the ROC curve.


Demographic and Clinical Characteristics

Table 1 shows the baseline demographic data for the subject groups. There was no significant difference in sex, age and education between the aMCI group and the control group. Compared with the controls, patients with aMCI showed significantly poorer performances on the Mini Mental State Examination, word list memory, word list recall, word list recognition, and constructional recall in the CERAD-K neuropsychological test (p<0.05).

Between-group Differences in WM Integrity of the 16 a Priori WM Tracts

Group comparison results of FA and MD values between the aMCI and the normal control group are shown in Figure 2.

Among 16 different WM tracts, 10 tracts (Fmaj, both CABs, both CINGs, both ILFs, both SLFPs and left SLFT) of aMCI group showed statistically significantly lower FA values than normal control group after age, sex, and total intracranial volumes corrected. In addition, 13 WM tracts of 16 tracts showed statistically significantly increased MD values in aMCI group, except 3 tracts (Fmin, right ATR and right SLFT). There were no statistical differences of FA and MD values of the CST between the aMCI group and the control group.

Diagnostic Performance and Receiver Operating Characteristic Curve Analysis

The diagnostic performances of selected 9 WM tracts (Fmaj, both CABs, both CINGs, both SLFPs and both ILFs) and sum of these tracts are shown in Table 2. Among FA and MD value of each tract, the FA value of left CAB showed highest AUC of 0.85 with a sensitivity of 88.2%, a specificity of 76.9%, a positive predictive value (PPV) of 78.6% and a negative predictive value (NPV) of 87%. The MD value of right CAB showed lowest AUC value of 0.65 with a sensitivity of 76%, a specificity of 53.8%, a PPV of 61.3% and a NPV of 70%. The ROC curve analysis of sum of 9 tracts is shown in Figure 3. The FA value of sum of 9 tracts showed AUC value of 0.98, a sensitivity of 96%, a specificity of 94.2%, a PPV of 94.1% and a NPV of 96.1%. The MD value of sum of 9 tracts showed AUC value of 0.95, a sensitivity of 84%, a specificity of 92.3%, a PPV of 91.3% and a NPV of 85.7%.


To the best of our knowledge, this is the first study on diagnostic validity of automated probabilistic tract specific analysis in discriminating aMCI from normal controls.

We analyzed DTI data of normal control and MCI patient group using automated technique with probabilistic tractography, TRACULA. There are two different conceptions of tractography methods; deterministic and probabilistic tractography.25) Deterministic method is based on the assumption of the eigenvector is parallel to the underlying dominant fiber direction in each image voxel. Then, this algorithm propagates a single pathway form a seed point.40) This method has a critical disadvantage of limited tracing a tract with crossing fibers, more than two different directional tracts in a voxel. The probabilistic method has been developed to attempt to resolve fiber crossings voxel and to model uncertainty.37) TRACULA performs global probabilistic tractography of 18 major WM pathways of brain with using prior information on tract anatomy from a set of training subjects. It constrains WM pathways in new subjects based on this prior anatomical knowledge. We attempted to get more reproducible result by adopting automated technique.

There was a previous study about DTI of normal control, MCI and AD patients using TRACULA analysis.41) They found out that several major WM tracts, especially cingulum-angular bundle, showed significant deterioration of WM integrity in MCI and AD patients. They demonstrated those WM alterations were observed even after correction of hippocampal volume. That could mean WM change in MCI and AD occurs not entirely dependent on hippocampal atrophic change. Gray matter pathology was not preceding condition of WM degeneration was observed in previous neuropathological study,42) more assigned to vascular disease. These studies support our attempt to investigate diagnostic accuracy of single DTI modality for aMCI patients without analyzing gray matter atrophic change.

Our results demonstrated WM degradations of multiple major WM tracts in aMCI with difference of MD value (in 13 tracts) and FA value (in 10 tracts). Especially, we found out that each memory-related tract showed good diagnostic performance in differentiation aMCI patient from normal control group with 0.65 to 0.85 range of AUC. Among those tracts, cingulum showed overall the best diagnostic performance as a single tract, similar to previous TRACULAR study of aMCI and AD.41) The cingulum is known as a tract contains efferent fiber from entorhinal-hippocampal complex,43) seems to reflect early alteration of aMCI patients.44)

In this study, we showed that combined FA and MD values of memory related tracts showed high diagnostic accuracy in both of FA and MD with 0.98, 0.95 of AUC respectively. Previously reported diagnostic performance of multimodal analysis with DTI and resting-state functional MRI (fMRI) was good, 96.3% accuracy and area of 0.953 under the ROC curve in discriminating aMCI from normal controls.45) In addition, another study also showed that combined use of FA value and cortical thickness of left temporal lobe improved the accuracy to diagnosing MCI compared with either measurement alone.21) Our results showed similar high diagnostic performance derived from single neuroimaging modality of DTI for differentiation of aMCI from healthy control group. To date, the medial temporal and hippocampus structural changes have been considered as pathological core of episodic memory impairment in the AD and aMCI.43) Moreover, prefrontal and retrosplenial cortex including posterior cingulate and precuneus structural and functional alterations were known to be involved in episodic memory impairment in AD and aMCI. As several WM tracts such as Fmaj, Fmin, CAB, CING ILF, SLFP and SLFT are linking these memory related gray matter structures, WM integrity disruption of these tracts might be complexly related to the pathologic process of aMCI and AD.

The tracts showed decreased WM integrity in our results were interestingly overlapped with previously reported regions of connectivity problem resting-state fMRI studies. Disruption of functional connectivity of default mode network was observed in previous studies4649) at posterior parietal cortex, the precuneus, posterior and anterior cingulated cortex, medial prefrontal cortex, hippocampus and thalamus. Further study using fMRI analysis and automated tractography is needed for better revealing of effective neuroimaging tool for aMCI patient.

Previous study showed result of FA was the least sensitive measurement among DTI indices such as FA, MD, radial diffusivity, axial diffusivity.13) However, our results revealed remarkable change of FA value for differentiating MCI group from normal control group. It is unclear why there is such difference of diagnostic accuracy of FA value, however it could be derived from different methodology. They used ROI measurement method otherwise our DTI metrics were obtained from tractography of major WM tracts. Further comparison study about different methodology will necessary to explore these different results.

The limitations of our study were as follows. First, as we included the subjects with normal appearing WM in this study, we could not investigate the effect of apparent WM pathology on WM integrity change in aMCI subjects. Therefore, the results of this study should not be generalized to aMCI with other apparent WM pathology such as leukoaraiosis and microbleeding. Indeed, aMCI is a heterogeneous entity due to various pathological substrates and characterized by different outcomes.50) Therefore, further study with pathological neuroimaging such as amyloid and tau positron emission tomography would increase more accurate diagnostic validity of DTI analysis in discriminating aMCI from normal controls. Second, as the TRACULA program does not provide the tractography of the fornix, we could not include the diagnostic validity of WM integrity of the fornix in this study. Several prior works showed the WM integrity of the fornix provided excellent diagnostic accuracy in discriminating aMCI and AD from normal controls.51) In addition, unlike the other WM tracts, FA values from the fornix were not influenced by the noise of crossing fibers.52) Hence, the inclusion of the fornix tract in the next version of TRACULA software would be increase validity of this program as AD biomarker analysis tool.

In conclusion, our results with aberrant WM integrity in the memory related WM tracts provided high diagnostic accuracy in discriminating aMCI from normal controls. These WM integrity changes suggest the automated probabilistic tractography methods might be promising neuroimaging tool for early detection of aMCI and AD patients. However, further larger studies will be needed to confirm real clinical benefits.


This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2015R1C1A1A02036578).

Fig. 1. White matter tracts reconstructed by automated probabilistic tractography.

ATR, anterior thalamic radiations; CAB, cingulum-angular bundle; CING, cingulum-cingulate gyrus bundle; CST, corticospinal tract; Fmaj, corpus callosum-forceps major; Fmin, corpus callosum-forceps minor; ILF, inferior longitudinal fasciculus; SLFP, superior longitudinal fasciculus-parietal terminations; SLFT, superior longitudinal fasciculus-temporal terminations; UNC, uncinate fasciculus.

Fig. 2. Group comparison results of fractional anisotropy (FA) and mean diffusivity (MD) values between the amnestic mild cognitive impairment (aMCI) and the normal control groups.

fmaj, corpus callosum-forceps major; fmin, corpus callosum-forceps minor; atr, anterior thalamic radiations; cab, cingulum-angular bundle; ccg, cingulum gyrus bundle; slfp, superior longitudinal fasciculus-parietal terminations; ilf, inferior longitudinal fasciculus; slft, superior longitudinal fasciculus-temporal terminations; unc, uncinate fasciculus; rh, right hemisphere; lh, left hemisphere.

*Statistically significant after age, sex, and total intracranial volumes corrected.

Fig. 3. Receiver operator characteristic curve analysis of fractional anisotropy (FA) and mean diffusivity (MD) values of memory related tracts (Fmaj, CAB, CING, SLFP, and ILF) between the amnestic mild cognitive impairment and the normal control groups.

Fmaj, corpus callosum-forceps major; CAB, cingulum-angular bundle; CING, cingulum-cingulate gyrus bundle; SLFP, superior longitudinal fasciculus-parietal terminations; ILF, inferior longitudinal fasciculus.


Demographic and clinical characteristics of study participants

Characteristic Control group (n=52)  aMCI group (n=50) p value 
Age (yr)69.2±6.471.1±6.9NS
Education (yr)10.4±4.49.7±3.2NS
Sex (male:female)20:3222:28NS
CERAD-K battery
 Verbal fluency13.9±3.912.2±3.5NS
 Word list memory18.5±4.57.0±3.4<0.0001
 Constructional praxis 9.4±1.58.7±1.9NS
 Word list recall7.7±1.82.3±1.8<0.0001
 Word list recognition9.9±1.26.5±1.7<0.0001
 Constructional recall6.9±2.93.2±2.9<0.0001

Values are presented as mean±standard deviation or number only.

aMCI, amnestic mild cognitive impairment; NS, not significant; CERAD-K, the Korean version of Consortium to Establish a Registry for Alzheimer’s Disease; BNT, 15-item Boston Naming Test; MMSE, Mini Mental Status Examination.

Sensitivity and specificity to predict aMCI with measurement of 5 memory related white matter (WM) tracts

WM tracts Sensitivity (%)  Specificity (%)  PPV (%)  NPV (%)  AUC 
Sum of 9 tracts

aMCI, amnestic mild cognitive impairment; PPV, positive predictive value; NPV, negative predictive value; AUC, area under the receiver operating characteristic curve; FA, fractional anisotropy; MD, mean diffusivity; Fmaj, forceps major; CAB, cingulum-angular bundle; CING, cingulum-cingulate gyrus; SLFP, superior longitudinal fasciculus; ILF, inferior longitudinal fasciculus.

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