Microglia and Autism Spectrum Disorder – overview of current evidence and novel immunomodulatory treatment options
Seung Min Bae 3, 3, 3*, Ji Yeon Hong 2, 2, 2, Jung Won Kim 1, 1, 1
1Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 2Department of Medicine, Severance Biomedical Science Institute, Yonsei University College of Medicine, 3Gachon University Gil Medical Center, Gachon College of Medicine
Received: December 26, 2017; Revised: March 12, 2018; Accepted: April 5, 2018; Published online: April 5, 2018.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Autism Spectrum Disorder (ASD) is a rapidly increasing heterogeneous neurodevelopmental syndrome, remarked by persistent deficit in social communication, and restricted, repetitive patterns of behavior and interest . Lately, Maternal Immune Activation (MIA) and micgroglial dysfunction in the developing brain has been gaining mounting evidence and leading to studies of various novel agents as treatment options. A few immunomodulatory treatment options - Luteolin, Minocycline, Suramin, Vitamin D, Gut microbiota – are discussed in the current article, regarding the current understanding of their mechanisms and evidence for potential clinical use. More studies are warranted to understand their exact mechanisms of action and to verify efficacy and safety in human subjects.
Keywords: Autism Spectrum Disorder, Maternal Immune Activation, Microglia, Immunomodulatory Treatment Options


e-submission

Archives