Changes In Pre And Post Electroconvulsive Therapy Serum Myostatin Levels In Patients With Treatment Resistant Depression
Cemil Çelik 1*, Abdullah Bolu 1, Taner Öznur 1, Mehmet Sinan Aydın 1, Yusuf Tokgöz 1, Özcan Uzun 1
Gülhane Education and Research Hospital, Department of Psychiatry
Received: July 4, 2017; Revised: September 5, 2017; Accepted: September 5, 2017; Published online: September 5, 2017.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Objectives: Myostatin is a growth factor which is investigated regarding musculoskeletal system. Albeit its effect on muscle mass is known, it is considered likely having other unknown effects as well, particularly on central nervous system. With this study, it is aimed to find out that what type of effect electroconvulsive therapy (ECT) does on myostatin in patients with treatment resistant depression.
Methods: Twenty nine patients with treatment resistant major depression and thirty healthy volunteers are included in the study. Pre and post ECT levels of myostatine were compared; also this results were compared to healthy controls.
Results: As a result of this study, it is found that electroconvulsive therapy affects serum myostatin levels to a significant degree (t=5.00; p<0.05). It is also found that there was a significant relation between serum myostatin levels and depression scores (r=0.392, p=0.035).
Conclusions: With the present study and similar ones, it can be understood that how electroconvulsive therapy achieves its effectiveness biologically.
Keywords: electroconvulsive therapy, depression, myostatin