DEPRESSIVE TEMPERAMENT IN RELATIVES OF PATIENTS WITH SCHIZOPHRENIA IS ASSOCIATED WITH SUICIDALITY IN PATIENTS WITH SCHIZOPHRENIA
Esra Yazici 1, Zerrin Cimen 2, Ipen Ilknur Unlu Akyollu 2, Ahmet Bulent Yazici 2*, Betul Turkmen 2, Atila Erol 1
1Department of Psychiatry, Sakarya University, Faculty of Medicine, Sakarya, Turkey , 2Department of Psychiatry, Sakarya University Training and Research Hospital, Sakarya, Turkey
Received: May 11, 2017; Revised: August 9, 2017; Accepted: August 11, 2017; Published online: August 11, 2017.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Background: Suicide is a major cause of death in patients with schizophrenia; thus, predicting and preventing suicide in patients with schizophrenia is examined in various studies. Affective temperaments which are accepted as precursors of mood disorders may be an important factor in predicting suicidality. This study investigated the relationship between affective temperaments of relatives of schizophrenia patients and suicidal thoughts and other clinical correlates of patients with schizophrenia.
Methods: Patients with schizophrenia and their first degree relatives are included to the study. All of the participants were evaluated with SCID-1 for DSM IV and relatives with active psychiatric diagnosis were excluded. Positive and negative symptom scale, clinical global impression scale, Turkish version of cognitive assessment interview were administered congruently to the patients. Relatives of the patients were evaluated with Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Auto-questionnaire (TEMPS-A).
Results. Depressive temperament scores of relatives of schizophrenic patients who had suicidal thoughts were higher than the scores of the relatives of the patients who did not have suicidal thoughts. Depressive temperament also predicted number of suicide attempts in regression analysis. Number of suicide attempts was also related with number of hospitalization and functionality of the patient.
Conclusion
Suicidality in schizophrenia is related with relatives' affective temperaments and patients' own positive symptom scores. The relationship between suicidal thoughts and depressive temperament is high lightened in this study
Keywords: suicide, schizophrenia, relatives, affective temperament, depressive mood


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