The levels of Vitamin D, Vitamin D Receptor, Homocysteine and Complex B Vitamin in Children with Autism Spectrum Disorders
Hatice Altun *, Ergül Belge Kurutaş , Nilfer Şahin , Olcay Güngör , Ebru Fındıklı
1Department of Child and Adolescent Psychiatry, Faculty of Medicine, Kahramanmaras Sutcu Imam Univercity, 2Department of Biochemistry, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 3Department of Child and Adolescent Psychiatry, Faculty of Medicine, Muğla Sıtkı Koçman University, 4Department of Pediatric Neurology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 5Department of Psychiatry, Faculty of Medicine, Kahramanmaras Sutcu Imam University
Received: May 3, 2017; Revised: July 29, 2017; Accepted: August 1, 2017; Published online: August 1, 2017.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome with an increasingly prevalent etiology,yet not full understood.In recent years,it has been thought that vitamin D,complex B vitamin levels and homocysteine are associated with environmental factors and are important in ASD.In addition,the vitamin D receptor (VDR) polymorphisms have been also reported to be important in the ASD etiology.The aim of this study was to examine the serum vitamin D and VDR,homocysteine,vitamin B6,vitamin B12 and folate levels in ASD.
Methods: In this study,serum vitamin D and VDR,homocysteine,vitamins B6,B12 and folate levels were determined in 60 patients with ASD (aged 3-12) and in 45 age-gender matched healthy controls.In addition,calcium,phosphorus and alkaline phosphatase,which are associated with vitamin D metabolism, were measured from serum in both groups.ASD severity was evaluted by the Childhood Autism Rating Scale (CARS).
Results: Serum vitamin D and VDR were substantially reduced in patients with ASD in comparision to control group.However,the homocysteine level was significantly higher and vitamin B6,vitamin B12 and folate were also reduced in patients with ASD.Other laboratory findings were similar in both groups.The total CARS score showed a positive association with homocysteine and a negative correlation with vitamins D,B6,B12, folate and VDR.
Conclusion: This comprehensive study,which examines many parameters has shown that low serum levels of vitamins D,B6,B12,folate and VDR as well as high homocysteine are important in the etiopathogenesis of ASD.However,further studies are required to define the precise mechanism(s) of these parameters and their contributions to the etiology and treatment of ASD.
Keywords: Autism spectrum disorder, Folate, Vitamin D, Vitamin B12, Vitamin D Receptor, Child, Homocysteine, Complex B vitamin, Vitamin B6


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