Different endocrine effects of an evening dose of amitriptyline, escitalopram, and placebo in healthy participants
Lukas Frase 1, John Peter Doerr 1, Bernd Feige 1, Maria Rechenbach 1, Bernd L. Fiebich 1, Dieter Riemann 1, Christoph Nissen 1, 2, 3*, Ulrich Voderholzer 1, 4
1Clinic for Psychiatry and Psychotherapy, Medical Center – University of Freiburg, Germany, 2University Hospital of Psychiatry and Psychotherapy Bern, Switzerland, 3Neuroscience Center, University of Bern, Switzerland, 4Schön Klinik Roseneck, Prien, Germany
Received: March 25, 2017; Revised: July 7, 2017; Accepted: July 10, 2017; Published online: July 10, 2017.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: The primary aim of this study was to further characterize the acute effects of amitriptyline and escitalopram on serum levels of ghrelin, leptin, cortisol and prolactin in healthy humans.
Methods: Eleven healthy male participants received a single dose of amitriptyline 75 mg (AMI), escitalopram 10 mg (ESC) or placebo (PLA) at 9:00 PM in a double-blind, randomized, controlled, repeated-measures study separated by one week. Fasting morning serum levels (7:00 AM) of ghrelin, leptin, cortisol and prolactin were assessed.
Results: A repeated measures multivariate analysis of variance revealed a significant main effect for the factor condition (AMI, ESC, PLA) on morning ghrelin and cortisol serum levels. Post-hoc analyses demonstrated a significant reduction of ghrelin levels after AMI in comparison to PLA, and a significant reduction of cortisol levels after AMI in comparison to both ESC and PLA. Other contrasts did not reach statistical significance.
Conclusion: Administration of a single dose of AMI, but not of ESC, leads to a significant reduction in morning serum ghrelin and cortisol levels. No effects on leptin and prolactin levels were observed. The differential impact of AMI and ESC on hormones might contribute to different adverse effect profiles of both substances.
Keywords: ghrelin, weight gain, cortisol, prolactin, leptin, adverse effects


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