Increased Neutrophil-Lymphocyte And Platelet-Lymphocyte Ratios In Male Heroin Addicts: A Prospective Controlled Study
Erdinc Cicek 1*, Basak Demirel 2, Ismet Esra Cicek 2, Aslı Seda Kırac 2, Ibrahim Eren 2
1Department of Psychiatry, Çumra State Hospital, Konya, Turkey, 2Department of Psychiatry, Research and Training Hospital, Konya,Turkey
Received: March 1, 2017; Revised: July 3, 2017; Accepted: July 3, 2017; Published online: July 3, 2017.
© The Korean College of Neuropsychopharmacology. All rights reserved.

The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are markers that can determine the presence of systemic inflammatory response. In this study, we examined the NLR and PLR levels in patients with heroin dependence compared to healthy controls.
The study sample included 90 male patients with heroin dependence aged 18-45 years and 60 healthy subjects who had similar socio-demographic characteristics as the patient group. The diagnoses of heroin dependence and other Axis I psychiatric disorders in the patient and control groups were screened with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (SCID-I). The extent of heroin addiction was assessed with the Addiction Severity Index (ASI).
The mean NLR and PLR levels of patients with heroin dependence were significantly higher than the control subjects (P=0.031 and P<0.001, respectively). Positive correlations were found between NLR, PLR and duration of the disorder.
Our results indicate that inflammatory processes may play a role in the pathophysiology of heroin dependence.
Keywords: Heroin, dependence, Neutrophil–lymphocyte ratio, Platelet–lymphocyte ratio