The Effects of Continuation-Maintenance Electroconvulsive Therapy on Reducing Hospital Re-Admissions in Patients with Treatment-Resistant Schizophrenia
Kyung Mook Choi 1, Soo-Hee Choi 1, 2, Jung Kyung Hong 1, Mi Hyun Lee 1, Joon Hyung Jung 1, Sang Hoon Oh 1, Dong Chung Jung 1, Sung Nyun Kim 1*
1Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea, 2Department of Psychiatry and Institute of Human Behavioral Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
Received: May 25, 2017; Revised: May 26, 2017; Accepted: May 29, 2017; Published online: May 29, 2017.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Objective: Continuation-maintenance electroconvulsive therapy ECT (C/M-ECT) is used to prevent relapse or recurrence in patients with severe mental illnesses. We aimed to investigate the effect of C/M-ECT on reducing hospital re-admissions in patients with treatment-resistant schizophrenia.
Methods: We applied a mirror-image design by retrospectively examining re-hospitalization rates of 18 patients with schizophrenia spectrum disorders. We compared the numbers of psychiatric admissions during the actual period over which C/M-ECT was administered with the same period prior to the beginning of C/M-ECT.
Results: The number of psychiatric admissions was reduced significantly during C/M-ECT 2.67 ± 1.33) compared with that of the same period prior to C/M-ECT (0.33 ± 0.77) (Wilcoxon signed rank Z = -3.663; p < 0.001).
Conclusion: This finding shows that C/M-ECT augmentation could successfully reduce the re-hospitalization rates in patients with treatment-resistant schizophrenia.
Keywords: Maintenance ECT, ECT augmentation, Clozapine resistance, Schizophrenia, Hospitalization