Clinical usefulness of aripiprazole treatment in a girl with Prader-Willi syndrome and psychosis
Wolfgang Briegel 1, 2*
1Leopoldina Hospital, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, 2Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg
Received: February 7, 2017; Revised: May 3, 2017; Accepted: May 10, 2017; Published online: May 10, 2017.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Prader-Willi syndrome (PWS) is a quite rare multi-systemic genetic disorder strongly asso-ciated with psychiatric illness in adults, especially psychosis. This report presents a 16 year old female with PWS and symptoms of brief psychotic disorder with a complete resolution of symptoms under aripiprazole medication. However, an exacerbation occurred after ari-piprazole reduction. Apart from a weight gain of about 2 kg over the course of two years, no adverse effects could be found. This first report on the use of aripiprazole in a subject with PWS and psychosis suggests that aripiprazole might be a promising treatment ap-proach in this distinct group of patients.
Keywords: Prader-Willi syndrome, case report, aripiprazole, psychosis, adolescent