Early postnatal valproic acid exposure increase the protein level of astrocyte markers in frontal cortex of rat
Tamanna Jahan Mony 1, Jae Won Lee 2, Sung Soo Kim 1, Wanjoo Chun 1, Hee Jae Lee 1*
1Department of Pharmacology, School of Medicine, Kangwon National University, Chuncheon, Gangwon, Republic of Korea, 2National Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungju, Chungbuk, Republic of Korea
Received: February 2, 2017; Revised: March 5, 2017; Accepted: March 29, 2017; Published online: March 29, 2017.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: In our previous study, we reported that valproic acid effects gliogenesis and increases the number of glial precursor cells during the early postnatal period.
Methods: As an ongoing study, using Immunoblotting analysis, we checked the level of glial protein and glial-derived factor markers in the frontal cortex of a rat brain at PND 21.
Results: The finding of the study suggests that, in the VPA group (p<0.05), early exposure induces increased precursor cell proliferation in the cortex and, later on, the expression level of glial protein cells was significantly increased.
Conclusion: Therefore we suggest that, alter gliogenesis and abnormal number of glial cells modulate the neurobiological dysfunction and induces the risk of neurodevelopmental disorders.
Keywords: Valproic acid, gliogenesis, Glial marker, Frontal barin, Postnatal period


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