Hippocampal subfields volume reduction in high schoolers with previous verbal abuse experiences
Sang Won Lee 1, 2, Jae Hyun Yoo 1, Ko Woon Kim 1, Dongchan Kim 3, HyunWook Park 3, Jeewook Choi 4, Martin H. Teicher 5, 6, Bumseok Jeong 1, 7*
1Laboratory of Clinical Neuroscience and Development, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea. , 2Department of Psychiatry, Kyungpook National University School of Medicine, Daegu, Republic of Korea., 3Department of Electrical Engineering, KAIST, Daejeon, Republic of Korea., 4Department of Psychiatry, Daejeon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Daejeon, Republic of Korea., 5Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America., 6Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, Massachusetts, United States of America., 7Center of Optics for Health Science, KAIST Institute, KAIST, Daejeon, Republic of Korea.
Received: November 15, 2016; Revised: February 22, 2017; Accepted: February 28, 2017; Published online: February 28, 2017.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objectives: Reduced hippocampal volume and alterations in white matter tracts have been frequently reported in adults having the history of emotional maltreatment. We investigated whether these structural change occur in adolescents with previous verbal abuse experiences.
Methods: Hippocampal subfield volume and white matter structural connectivity measures were assessed in 31 first year male high school students with various degrees of exposure to parental and peer verbal abuse (VA).
Results: The high VA group showed significant volume reduction in the left CA1 and left subiculum compared to the low VA group (p<0.05). Volumes of left hippocampal subfields CA1 and subiculum were negatively correlated with previous VA experiences (p<0.05). Increased mean diffusivity (MD) of the splenium of the corpus callosum was related to high VA score across all subjects (p<0.05). There was an inverse relationship between volume of the CA1 and subiculum and MD of the splenium (p<0.05).
Conclusions: Exposure to parental and peer VA may affect development of the left hippocampal subfields and the splenium of corpus callosum and be discernible during adolescence.
Keywords: Hippocampal subfields, Verbal abuse, Splenium


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