THIOL DISULFIDE HOMEOSTASIS IN SCHIZOPHRENIC PATIENTS USING ATYPICAL ANTIPSYCHOTIC DRUGS
Halef Okan DOĞAN 1, Halef Okan DOĞAN 1*, Erdal ERŞAN 2, Erdal ERŞAN 2, Hüseyin AYDIN 1, Hüseyin AYDIN 1, Serpil ERDOĞAN 3, Serpil ERDOĞAN 3, Serpil ERŞAN 1, Serpil ERŞAN 1, Murat ALIŞIK , Murat ALIŞIK , Sevtap BAKIR , Sevtap BAKIR , Özcan EREL , Özcan EREL , Derya Koç , Derya Koç
1Department of Biochemistry, Cumhuriyet University, Faculty of Medicine, 1Department of Biochemistry, Cumhuriyet University, Faculty of Medicine, 2Sivas Numune Hospital, Department of Psychiatry, 2Sivas Numune Hospital, Department of Psychiatry, 3Ankara Ataturk Education and Research Hospital, Department of Clinical Biochemistry, , 3Ankara Ataturk Education and Research Hospital, Department of Clinical Biochemistry,
Received: October 12, 2016; Revised: December 30, 2016; Accepted: January 1, 2017; Published online: January 1, 2017.
© The Korean College of Neuropsychopharmacology. All rights reserved.

Abstract
Objective: Schizophrenia is a severe, debilitating mental disorder characterized by behavioral abnormalities. Although several studies have investigated the role of oxidative stress and the effects of antipsychotic drugs on oxidative markers in schizophrenia, adequate information is not available on these issues. The aim of this study is to determine the changes in oxidative status and thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs. Methods: 30 schizophrenic patients using atypical antipsychotic drugs and 30 healthy controls were included this study. The concentrations of total oxidant status (TOS), total antioxidant status (TAS), native thiol, total thiol, and disulfide levels were determined in the study population. Results: The TAS (p = 0.001), total thiol, and native thiol levels (p < 0.001) were higher in the patients compared to the controls, whereas the TOS and disulfide levels were lower in the patients than in the controls (p < 0.001). Conclusions: These results may suggest that atypical antipsychotic drugs have a useful therapeutic effect by reducing oxidative stress via the inhibition ofthe formation of disulfidebonds.The study population number was one of the limitation of this study. Therefore, further studies are needed to establish the association between thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs.
Keywords: Schizophrenia, atypical anti-psychotics, thiol, disulfide


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